Biomarkers, the Genome, and the Individual

Betty K Mansfield bkq at ornl.gov
Sun Feb 16 13:18:30 EST 1997


  
TENTATIVE  MEETING OUTLINE

                  BIOMARKERS, THE GENOME & THE INDIVIDUAL---

         WORKPLACE AND MEDICAL IMPLICATIONS OF A RAPIDLY EVOLVING
                                TECHNOLOGY

                        Charleston, South Carolina
                               May 4-8, 1997

SUNDAY MAY 4 (The Francis Marion Hotel, Charleston)

4-7 PM    Registration
7 PM      Keynote address: Dr. Joshua Lederberg* (Nobel Laureate)
8 PM      Reception
                           ____________________


MONDAY MAY 5 (Physicians Memorial Auditorium-The College of Charleston)

SECTION:  INTRODUCTION AND BACKGROUND

                Session Chairman:  Dr. Lawrence Mohr*, MUSC

8:20 AM   Special Announcements
8:30 AM   Introduction and Goals (Dr. Lawrence Mohr*, MUSC)
8:45 AM   What is a Valid Biomarker ? (Dr. Paul Schulte*, NIOSH)
9:05 AM   Historical Perspectives (Dr. Michael Gochfeld*, EOSHI)
9:25 AM   Laboratory Perspectives (Dr. Rogene Henderson*, ITRI)

9:45 AM   Panel Discussion:  (Chair:  Dr. Carol Henry*, DOE)

10:15 AM  COFFEE BREAK

10:45 AM  Clinical Perspectives (Dr. Robert McCunney*, MIT)
11:05 AM  Ethical Perspectives (Dr. Tom Murray*, Case Western)
11:25 AM  Public Policy and Costs (Dr. Bernard Goldstein*, EOSHI)

11:45 AM  Panel Discussion:  (Chair:  Dr. Paul Schulte*, NIOSH)

12:15 PM  LUNCH BREAK

SECTION:  TECHNOLOGIES FOR MEASURING PRIOR EXPOSURES

               Session Chairman:  Dr. Mort Mendelsohn*, LLNL

1:30 PM   Technical Basis for ESR dosimetry (Dr. Marc Desrosiers*, NIST)
1:50 PM   Validation of ESR in the Atomic Bomb Survivors Studies (Dr.
          Nori Nakamura*, RERF, Japan)
2:10 PM   X-ray Fluorescence (Dr. Howard Hu*, Harvard)

2:30 PM   Panel Discussion:  (Chair:  Dr. Dieter Regulla*, GSF, Munich,
          Germany)

3:00 PM   COFFEE BREAK

3:30 PM   Stable Chromosomal Aberrations (Dr. Jim Tucker*, LLNL)
3:50 PM   Immune Biomarkers (Dr. Bob Vogt*, CDC)
4:10 PM   Isotopic Ratios (Dr. Joseph Graziano*, Columbia)

4:30 PM   Panel Discussion:  (Chair:  Dr. Bernard Goldstein*, EOSHI)

SECTION:       STORAGE OF DNA SAMPLES

           Session Chairman:  Dr. Mark Rothstein*, U. of Houston

5:00 PM   Large Scale Genomic Tagging at DOD (Dr. Victor Weedn*, AFIP)
5:20 PM   Issues Related to the Re-analysis of Stored Samples (Dr. Ellen
          Clayton*, Vanderbilt Medical School)

5:40 PM   Panel Discussion:  (Chair:  Dr. Eula Bingham*, U. of Cincinnati)
                           ____________________


TUESDAY MAY 6 (Physicians Memorial Auditorium-The College of Charleston)

SECTION:  TECHNOLOGIES FOR MEASURING RECENT EXPOSURES

         Session Chairman:  Dr. Richard Albertini*, U. of Vermont

8:20 AM   Special Announcements
8:30 AM   Volatile Chemicals and the E2R Monitor (Dr. Karla Thrall*, PNL)
8:50 AM   Tubular Proteinurea (Dr. Richard Wudeen*, New Jersey)
9:10 AM   DNA Adducts (Dr. Kari Hemminki*, Karolinska, Sweden)

9:30 AM   Panel Discussion:  (Chair:  Dr. Leopold Miksche*, Bayer AG,
          Germany)

10:00 AM  COFFEE BREAK

10:30 AM  DNA Adducts using Accelerator Mass Spec (Dr. Ken Turtletaub*,
          LLNL)
10:50 AM  Protein/haemoglobin Adducts for TCE exposure (Dr. David
          McMillan*, MUSC)

11:10 AM  Panel Discussion:  (Chair:  Dr. Mort Mendelsohn*, LLNL)

SECTION:  BIOMARKERS OF METABOLIC SUSCEPTIBILITY

            Session Chairman:  Dr. Paul Brandt-Rauf*, Columbia

11:30 AM  P 450 and Chemical Metabolism (Dr. Peter Shields*, NCI)
11:50 PM  Acetylation-Related Susceptibilities of Metabolism (Dr. F.
          Kadlubar*, NCTR)
12:10 PM  Glutathione S-transferase (Dr. Brian Ketterer*, UK)

12:30 PM  Panel Discussion:  (Chair:  Dr. Roger McClellan, CIIT)

1:00-2:00 PM   LUNCH BREAK

SECTION:  GENOMICS AND TECHNOLOGY DEVELOPMENTS

            Session Chairman: Dr. Lee Hood*, U. of Washington

2:00 PM   Scientific Basis of Genomic Technologies (Dr. Lee Hood*, U. of
          Washington)
2:20 PM   High Density DNA Chip Arrays (Dr. Rob Lipshutz*, Affymetrix)
2:40 PM   mRNA and the Analysis of Expressed Genes (David Botstein,
          Stanford)

3:00 PM   Panel Discussion:  (Chair: Dr. Marvin Frazier*, DOE)

3:30 PM   COFFEE BREAK

4:00 PM   Lab-on-a-chip (Dr. Lawrence A. Bock, Caliper Technologies)
4:20 PM   Mass Spectra DNA Tags for Multiplex Sequencing (Dr. George Church,
          Harvard)
4:40 PM   Biomarker Potential of PCR (Dr. Glen Evans*, U. of Texas)

5:00 PM   Panel Discussion:  (Chair:  Dr. Elbert Branscomb*, LLNL)

                           ____________________

7-9:00 PM POSTERS AND DISPLAYS (Cash Bar) -The Francis Marion Hotel

Progress in Diagnostics Kit Technology for Screening for Susceptibility:

o    Large pharmaceutical companies (Bayer AG*, Glaxo Wellcome, Smith-
     Kline, Merck, Pfizer)
o    Other companies:    Monsanto, Sequana Therapeutics, Nanogen, Hyseq,
                    Pharmacia Biotech, Vysis, Amgen, etc.

                           ____________________


WEDNESDAY MAY 7 (Physicians Memorial Auditorium-The College of Charleston)

SECTION:  PRACTICAL APPLICATIONS OF BIOMARKERS

          Session Chairman:  Dr. Barry Johnson*, Director, ATSDR

8:20 AM   Special Announcements
8:30 AM   Practical Uses of Biomarkers in Population Studies (Dr. Geoffrey
          Howe*, Columbia)
8:50 AM   Beryllium Biomarkers (Dr. Lee Newman*, National Jewish)
9:10 AM   Biomarkers for Aflatoxin (Dr. Regina Santella*, Columbia)

9:30 AM   Panel Discussion (Chair:  Dr. Robert McCunney* MIT)

10:00 AM  COFFEE BREAK

10:30 AM  Biomarkers and Models of Radiation Exposure (Dr. Mort
          Mendelsohn*, LLNL)
10:50 AM  Biomarker Calibration for Estimating Risk (Dr. Leopold Miksche*,
          Bayer AG, Germany)
11:10 AM  Biomarkers of Pulmonary Toxicity (Dr. Alfred Bernard*, Louvain,
          Belgium)
11:30 AM  Biomarkers of Reproductive Toxicity (Dr. Don Mattison*, U. of
          Pittsburgh)

11:50 AM  Panel Discussion (Chair:  Dr. Paul Seligman*, DOE)

12:30-1:30 PM  LUNCH BREAK

SECTION:  PRACTICAL APPLICATIONS OF BIOMARKERS (Cont.)

          Session Chairman:  Dr. Eula Bingham*, U. of Cincinnati

1:30 PM   Mutant Oncoprotein Biomarkers in Chemical Carcinogenesis
          (Dr. Paul Brandt-Rauf*, Columbia)
1:50 PM   Benzene Metabolites and Benzene Chromosomal Biomarkers
          (Dr. Martyn Smith, Berkeley)
2:10 PM   Somatic Mutations (Dr. Richard Albertini*, U. of Vermont)

2:30 PM   Panel Discussion (Chair:  Dr. Dale Hattis*, Clark U.)

3:00 PM   COFFEE BREAK

3:30 PM   Cotinine as a Biomarker of Smoke Exposure (Dr. Linda Youngman*,
          Oxford, UK)
3:50 PM   Ethnic Variation and Genetic Susceptibility: G6PD (Dr. David
          Jollow*, MUSC)
4:10 PM   Breast Cancer Screening and Ethnic Variation (David Goldgar,
          IARC, France)

4:30 PM   Panel Discussion  (Chair:  Dr. Carol Redmond*, MUSC)
                           ____________________

THURSDAY MAY 8 (Physicians Memorial Auditorium-The College of Charleston)

SECTION:  ETHICAL CONSIDERATIONS

               Session Chairman:  Dr. Charles Epstein, UCSF

8:20 AM   Special Announcements
8:30 AM   Ethical Issues (Dr. Charles Epstein, UCSF)
8:50 AM   Government Uses of Genetic Information (Dr. Barry Johnson*,
          ATSDR)
9:10 AM   The Uses of Genetics in the Workplace (Dr. Eula Bingham*,
          U. of Cincinnati)
9:30 AM   Employers Perspective (Dr. Joe Cannola, Mobil Corporation)

9:50 AM   COFFEE BREAK

10:20 AM  Non-Medical Uses of Genetic Information (Mark Rothstein*,
          U. of Houston)

10:50 AM  JUDICIAL PANEL

          Biomarkers, Scientific Validity and the Judicial Process
          (The Hon. Richard A. Levie*, Deputy Presiding Judge, Civil
          Division, Superior Court  of the District of Columbia,
          The Hon. Thomas S. Ellis, III*, Judge, United State District
          Court for the District of Eastern Virginia, and Dr. Franklin
          Zweig*, President, EINSHAC)

11:30 AM  GENERAL DISCUSSION

          Panel:    Drs. Charles Epstein, Barry Johnson*, Larry Mohr*,
               Mort Mendelsohn*, Carol Henry*, Judges Richard Levie*,
               and Thomas Ellis*.

12:30          Closing remarks (Dr. Lawrence Mohr*, MUSC)

                           ____________________

MEETING ADJOURNS

* Confirmed as of 02/05/97

                                  HOTELS

May is peak tourist season in Charleston, SC and we advise you to make your
room reservations as early as possible.  To receive special rates, please
contact one of the following hotels on or before April 1, 1997, and refer to
the MUSC BIOMARKER CONFERENCE room block. Please add 12% tax to these hotel
room rates.

Francis Marion Hotel:  $109.00 per night  (803) 722-0600
(Please inform reservationist if you are a federal government employee for
a discounted room rate.  A limited number of these rooms are available on a
first call-first serve basis.)

Quality Inn:  $74.00 per night  (803) 722-3391

Hampton Inn:  $89.00 per night (803) 723-4000

Hawthorn Suites Hotel: $115.00 per night (803) 577-2644

To receive a full registration packet, please call 1-800-277-3239 or fill
out the form below and fax to Jill Yarnall at 1-803-727-6464 or mail to:

Biomarker Conference
Medical University of South Carolina
Environmental Hazards Assessment Program
156 Rutledge Avenue
Charleston, South Carolina  29403

Registration information is available on the Internet through our website
www.ehap.musc.edu

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