P450/bionet.molecules.p450 PASSES: 143 YES to 3 NO

BIOSCI Administrator biosci-help at net.bio.net
Sun Jan 19 17:19:23 EST 1997

I am pleased to announce that the proposal to create
P450/bionet.molecules.p450 passed by a vote of 143 YES to 3 NO.  We
will proceed to create this newsgroup.

E-mail users, PLEASE do NOT request e-mail subscriptions until a
formal announcement is made in this forum indicating that the
newsgroup is ready for operation.


				Dave Kristofferson
				BIOSCI/bionet Manager

				biosci-help at net.bio.net


Proposal for P450/bionet.molecules.p450

USENET newsgroup name:  bionet.molecules.p450

Status:			Unmoderated

One line Description:   Research on cytochrome P450

Mailing list name:      P450

E-mail addresses:       p450 at net.bio.net
                        p450 at daresbury.ac.uk

Discussion leader:      Dr. A. Zimmerlin
                        Alfred.zimmerlin at fmi.ch
Newsgroup Charter:

bionet.molecules.p450 is a forum for scientific discussions and a
source of information for the community of biologists interested in any
aspect of cytochrome P450 research.

Functions of the newsgroup:

The newsgroup will facilitate rapid communication among research
scientists, educators and industries investigating cytochrome P450
function, structure, mechanism, biochemistry and molecular biology.

Formation of this newsgroup will provide :

- a forum for the discussion of ideas, problems, and recent
developments in the study of P450;

- a means of obtaining practical advice and answers to frequently
asked questions;

- a means of obtaining research protocols, strains, unique reagents
(e.g.inhibitors, substrates, antibodies, cDNA clones, primers and gene
sequences, DNA libraries, mutants, etc.);

- a means of developing collaborations between laboratories;

- a bulletin board for any announcements concerning meetings,
congresses, new informational databases, job offers, funding sources
of interest, etc., related to P450 research.

Discussion topics will include (among other more specific topics):

- substrates and inhibitors,
- marker activities,
- xenobiotic metabolism,
- physiological role,
- biosynthetic forms,
- extrahepatic forms,
- purification,
- antibodies and cross-reactivity
- isozyme profiling,
- drug interactions,
- reconstitution of activity,
- types of reactions,
- catalytic mechanism,
- regulation (hormone, age, gender, senescence, xenobiotics,...),
- crystallization and three-dimensional models,
- active site topology,
- model systems,
- cloning strategies,
- evolution and nomenclature,
- phylum specific P450s,
- genetic polymorphisms,
- protein-protein  and lipid-protein interactions,
- posttranslational modification,
- heterologous expression.
- computer assisted "sequence-structure-function" relationships,
- prediction of drugs side and toxic effects,
- P450 resourses in the Internet.

Discussions on regulation and function of related enzyme systems such as
peroxidases, FMO's, GST's, UDPGT's, NAT's, etc., are welcome.

This news group will not be moderated (edited). Participants shall
adhere to the general regulations regarding posting to news groups: a)
individuals posting information to this forum should use proper
"netiquette", b) the forum is not intended to aid students with their
homework assignments, c) the forum is used only for non-commercial
purposes, d) individuals must avoid conflicts of interest when posting

Subscribers are welcome from universities or any academic institutions,
government agencies, medical institutions, and industrial or commercial
organizations. Contributions within the functions outlined above are

Dr. Alfred Zimmerlin
Ciba-Geigy AG
Drug Metabolism and Exploratory Toxicology
CH-4002 Basel
Tel: (41) 616963101
Fax: (41) 616966212

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