New Release 1.1 - ProClass Protein Family Database and ProQuery Program

wu at wu at
Tue Jul 1 13:26:49 EST 1997

The Bioinformatics Research Group of the University of Texas Health Center at
Tyler is pleased to announce Release 1.1 of its ProClass Protein Family
Database and ProQuery ProClass Query Program.  The database is available for 
on-line search at:

Free copies of the ProClass Database and ProQuery Program can be obtained via 
anonymous FTP to:

The ProClass Protein Family Database is a non-redundant database organized
according to family relationships as defined collectively by PIR superfamilies
and ProSite patterns.  The objectives are to facilitate protein family
information retrieval, unveil domain and family relationships, and classify
multi-domained proteins. This is achieved by combining global and motif 
sequence similarities into a single classification scheme.  The current 
ProClass release consists of 91,319 sequence entries retrieved from 
PIR-international (Release 52.0, March 1997) and SwissProt (Release 34.0, 
November 1996) databases.

Major new features of ProClass Release 1.1 are:

  - Query program distribution: Newly available is the ProQuery program with
    which one can query ProClass database for record retrieval using various
    search keys.  The program can be installed on UNIX machines for use in
    batch-mode or via WWW interface. 
  - New links: Hypertext links to PIR_ALN superfamily/domain multiple sequence 
    alignments, PIR superfamily memberships, and ProDom protein domain database 
    are provided in this release, in addition to links to SwissProt, ProSite
    and PIR databases.
  - New family members: Also provided is a list of family members which were 
    not catalogued in ProSite (Release 13.0) or PIR (Release 51.0) but
    identified by our GeneFIND family identification system 
Please cite the following reference in publications that benefit from the
ProClass database:

    Wu, C. H., Zhao, S. and Chen, H. L. (1996). A protein class database
    organized with ProSite protein groups and PIR superfamilies. Journal
    of Computational Biology, 3(4), 547-561.

If you have any questions or comments, please contact me at wu at

Cathy Wu, Ph.D.
Associate Professor of Biomathematics
University of Texas Health Center at Tyler
P. O. Box 2003, Tyler, TX 75710
E-Mail	: wu at
Fax	: (903) 877-5914
Phone	: (903) 877-7962      

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