Army Research Announcement: Neurotoxin Exposure Treatment Research Program

USAMRAA at aibs usamraa at
Mon Jul 7 12:12:15 EST 1997

[Commerce Business Daily: Posted July 02, 1997]
>From the Commerce Business Daily Online via GPO Access

CLASSCOD: A--Research and Development
OFFADD: Director, USAMRAA, 820 Chandler St, Fort Detrick, MD 21702-5014
SOL CBD970-6000-0001
POC Craig D. Lebo, Contracting Officer (Site Code DAMD17)

DESC: Neurotoxin Exposure Treatment Research Program - The U.S. Army
Medical Research and Materiel Command is soliciting research proposals for
studies on the pathophysiology and treatment of neurodegenerative
diseases, including Parkinson's disease, and including environmental and
stress exposure factors encountered in military operations which may be
neurotoxic or lead to neurodegenerative conditions. An improved
understanding of the pathophysiology of neurodegerative diseases will form
the basis of potential preventive measures against the effects of military
threat agents and military operational hazards, and also lead to treatment
interventions for Parkinson's disease. This effort is coordinated with
research programs of the National Institutes of Neurological Disorders and
Stroke. We solicit proposals on a broad range of basic and applied
science, including but not limited to these areas of interest: 

(1) mechanisms of damage and protection against neural cell death,
including regulation of excitotoxins such as glutamate, oxidative stress
effects, and the protective role of anticonvulsants, 

(2) development and validation of new approaches to neuropsychological
testing to improve early detection of neurodegenerative diseases, 

(3) new therapeutic strategies for the treatment of neurodegenerative
disease, including neural cell transplantation, neuroprotection, and
alteration of cell biology through gene regulation and  other novel

(4) influence of environmental factors such as exposure to environmental
toxins, toxic military threat agents, infectious particles, and chronic
psychological stress in the mediation of neural cell death. 

Proposals will be selected for funding on the basis of scientific quality
as determined through an independent scientific peer review and potential
military relevance. Potential application to military populations will be
considered in this award. Projects are typically 2-4  years in duration
and must be completed by 30 Sep 2003. Up to $23M is available for the
lifespan of these projects. Proposals must be submitted according to
general instructions contained in the Broad Agency Announcement 95-1 (see 

Letters of intent containing a proposed title, brief description of
project scope (<150 words), and investigator and institution
identification, are required by 15 September 1997. 

Full proposals are due by 4:00 pm EST, Wednesday, 15 October 1997.
Investigators will be notified about funding recommendations by March
1998. Send letters of intent and proposals to: Commander, U.S. Army
Medical Research and Materiel Command, ATTN: MCMR-AAA (Neurotox), 820
Chandler Street, Fort Detrick, MD 21702-5014.
EMAILADD: craig_lebo at

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