Genome Analysis: Strategies, Medical and Industrial Applications

[Bernd Drescher]

             2nd Beutenberg Symposium on
       "Genome Analysis: Strategies, Medical and
              Industrial Applications"
          December 11-13, 1997, JENA, Germany

-------------------------------------------------------------------------
     The goal of this meeting is to discuss the
     latest results of genome research. We will have
     sessions on Small & Model Organisms, the Human
     Genome Project, Molecular Medicine and Human
     Diversity, Microsystems Technology in Genome
     Research & Diagnostics, and Ethical Problems.
     
     A special focus of the meeting is to bring
     together academic researchers and specialists
     and practitioners from industry to connect the
     scientific benefits with the interests of
     industry and business. Another central issue of
     the meeting is to discuss the potential
     applications of genome research for medicine,
     in particular, new strategies for the
     development of drugs, the rapies and diagnostic
     tools. The meeting should help people in the
     fields of structural and functional genome
     analysis to exchange ideas that will be
     universally applicable rather than
     system-oriented.
-------------------------------------------------------------------------
     

Registration and further information: http://genome.imb-jena.de/BBS97/



ORGANIZERS: Andre Rosenthal (IMB Jena & metaGen Berlin) and Hanspeter Saluz
(HKI Jena)

CO-ORGANIZER
V. Rosenbaum (DECHEMA)

SCIENTIFIC ADVISORY BOARD & INVITED SPEAKERS

M. Albin (PE Applied Biosystems, Foster City) A. Ballabio (Milano) R.
Balling (Munich) C. Bertram (Heidelberg) Brauer (Hoechst AG) S. Brenner (La
Jolla) M. Catenhusen (Bonn) U. Claussen (Jena) Ch. Coutelle (London) K.E.
Davis (Oxford) L. Doucette-Stamm (Ge nome Therapeutics, Boston) B. Efcavitch
(PE Applied Biosystems, Foster City) C. Freiberg (Bayer AG) D. Ganten
(Berlin), H. Lehrach (Berlin), H. zur Hausen (Heidelberg) D. Harris
(Amersham International) M.J. Heller (Nanogen, San Diego) J. Hoheisel
(Heidel berg) B.-M. Hill (Cologne) S.J.M. Jones (Hinxton) R. Johnston
(Molecular Dynamics, Sunnyvale) S. Lombardi (PE Applied Biosystems, Foster
City) S. Kenwrick (Cambridge) H. P. Klenk (TIGR, Rockville) P. Lichter
(Heidelberg) S.E. Lincoln (Incyte Pharmaceutical , Palo Alto) D. Lockhart
(Affymetrix, Santa Clara) W. Mewes (Munich) R. McCombie (Cold Spring Harbor)
M. Morgan (Wellcome Trust, London) A. Poustka, (Heidelberg) G. Rappold
(Heidelberg) J. Reich (Berlin) T. Sasaki (Tsukuba) W. Schleuning (Schering
AG) M.B . Soares (Iowa City) K. Sperling (Berlin) G. Stock (Schering AG,
Berlin) J. Straus (Munich) M. Strauss (Berlin) J. Sulston (Hinxton) L.-C.
Tsui (Toronto) M. Vaudin (Hinxton) C. Venter (TIGR, Rockville) D. Wang
(Cambridge) J. Weissenbach (Evry)


                                 Programme

GENOME ANALYSIS: STRATEGIES, MEDICAL AND INDUSTRIAL APPLICATIONS
-------------------------------------------------------------------------
Wednesday, December 10, 1997
-------------------------------------------------------------------------
16:00-19:00 Registration
19:00-21:00 Reception

-------------------------------------------------------------------------
Thursday, December 11, 1997
-------------------------------------------------------------------------

07:30-09:00 Registration
09:00-09:30 Opening Address

1st Session Small & Modell Genomes

Chairpersons: R. McCombie, L. Doucette Stamm

09:30-10:00 - Microbial genomics at TIGR
H.-P. Klenk, TIGR, Rockville, USA

10:00-10:30 - Rhizobium NGR 234: sequencing and transcript analysis
C. Freiberg, Bayer AG, Wuppertal, Germany

10:30-11:00 - Bacterial genome sequencing and analysis at Genome
Therapeutics Corp.
L. Doucette-Stamm, Genome Therapeutics Boston, USA

11:00-11:30 - Sequencing of the plastide genome of the reed algae Cyanidium
caldarium RK1
G. Gloeckner, Jena, Germany

11:30-12:00 Coffee Break

12:00-12:30 - The Wellcome Trust pathogen sequencing intiative
M. Morgan, The Wellcome Trust, London, UK

12:30-13:00 - What can we learn from the sequence of S. cerevisae
W. Mewes, Munich, Germany

13:00-14:00 Lunch

14:00-14:30 - Dictyostelium - another eukaryotic model organism?
A. Noegel, Cologne, Germany

14:30-15:00 - The C. elegans genome: towards completion
S.J.M.Jones, Hinxton, UK

15:00-15:30 - Arabidopsis genome sequencing
R. McCombie, Cold Spring Harbor, USA

15:30-16:00 - The rice genome: what do we learn by the cereal model plant?
T. Sasaki, Tsukuba, Japan

16:00-16:30 Coffee Break

2nd Session The Human Genome Project

Chairpersons: M. B. Soares, A. Balabio

16:30-17:00 - Generation of subtracted libraries enriched for novel cDNA's
M.B. Soares, Iowa City, USA

17:00-17:30 - LifeSeq - a comprehensive human EST database?
S.E. Lincoln, Incyte Pharmaceutical, Palo Alto, USA

17:30-18:00 - Drosophila-related expressed sequences (DRES): from
bioinformatic links towards functional similarities between man and fly
A.Ballabio, Milano, Italy

18:00-18:30 - Human mapping, sequencing and analysis at the Sanger Centre
M. Vaudin, Hinxton, UK

18:30-19:00 - The Jena human genome sequencing centre: analysis of large
genomic sequences of human chromosomes X, 21 & 7
A. Rosenthal, Jena, Germany

-------------------------------------------------------------------------
Friday, December 12,
-------------------------------------------------------------------------

09:00-09:30 - Capillary array electrophoresis in DNA sequencing
D. Harris, Amersham International, UK

09:30-10:00 - Advanced methods in automated DNA sequencing
S. Lombardi, PE Applied Biosystems, Foster City, USA

3rd Session Molecular Medicine & Human Diversity

Chairpersons: L.-C. Tsui, S. Kenwrick

10:00-10:30 - Short stature/Turner syndrome caused by the SHOX gene
G. Rappold, Heidelberg, Germany

10:30-11:00 - Molecular biology behind Werner's syndrome that accompany
premature aging symptoms
Y. Furuichi, Kanagawa, Japan

11:00-11:30 Coffee Break

11:30-12:00 - Genotype/phenotype correlation in Cystic Fibrosis - overview
L.-C. Tsui, Toronto, Canada

12:00-12:30 - Neural cell adhesion molecule L1: insights into function from
disease mutations
S. Kenwrick, Cambridge, UK

12:30-13:00 Cloning a putative human suppressor gene in 10q25.3-26.1 deleted
in malignant brain tumors
A. Poustka, Heidelberg, Germany

13:00-13:30 - Exon-scanning sequencing of the human gene for Ataxia
Telangiectasia in 120 patients
M. Platzer, Jena, Germany

13:30-14:30 Lunch

14:30-15:00 - Somatic gene therapy using viral vectors
M. Strauss, Berlin, Germany

15:00-15:30 - Integrin mediated gene transfer
Ch. Coutelle, London, UK

4th Session Microsystem Technology in Genome Research & Diagnostics

Chairpersons: D. Lockhart, D. Wang

15:30-16:00 - High-throughput expression profiling using Affymetrix chip
technology
D. Lockhart, Affymetrix, Santa Clara, USA

16:00-16:30 - Integrated microelectronic DNA hybridization systems for
genomic research and diagnostic Applications
M.J. Heller, Nanogen, San Diego, USA

16:30-17:00 - A third generation genetic map of the human genome: single
nucleotide polymorphisms (SNP) Analysed on high- density oligonucleotide
arrays
D. Wang, Cambridge, USA

17:00-17:30 Coffee Break

17:30-18:00 - Gene expression using microarray spotting technology
R. Johnston, Molecular Dynamics, Sunnyvale, USA

18:00-18:30 - Microsystem technology at PE Applied Biosystems
M. Albin, PE Applied Biosystems, Foster City, USA

18:30-19:00 - Functional analysis using chip technology
S. Woelfl, Jena, Germany

19:00-19:30 - Array and chip technology in functional genomics

H. Lehrach, Berlin, Germany

-------------------------------------------------------------------------
Saturday, December 13, 1997
-------------------------------------------------------------------------

09:00-09:30 - Sequencing by hybridization - a fresh look
J. Hoheisel, Heidelberg, Germany

09:30-10:00 - From Molecular Cytogenetics to DNA chips
P. Lichter, Heidelberg, Germany

5. Session Academia, Industry & Society

Chairpersons: W. D. Schleuning, J. Straus

10:00-10:30 - Genomics at the Schering AG
W.D. Schleuning, Schering AG, Germany

10:30-11:00 - Patents on human genes and international patent laws
J. Straus, Munich, Germany

11:00-11:30 Coffee Break

11:30-12:00 - Genome research reflected by the German public
M. Catenhusen, Bonn, Germany

12:00-12:30 - The price of neglected history
B.-M. Hill, Cologne, Germany

12:30-13:30 Lunch

6. Session New Technology from Industry

13:30-15:00 Six selected talks from abstracts and applications

(6 speakers giving a 15-minute talk each)