Homologous Bacterial Genes Database

[Guy Perriere]

                    HOBACGEN Release 4 (February 1999)


     The  first  public release of HOBACGEN (the Homologous Bacterial
     Genes Database) is  now  available. Information on how to access
     and use this system is available at URL:

            http://pbil.univ-lyon1.fr/databases/hobacgen.html

     HOBACGEN  is  a  database  system  that contains all the protein
     sequences of bacteria  organized into families. It allows one to
     select  sets  of  homologous genes from bacterial species and to
     visualize  multiple  alignments  and  phylogenetic  trees.  Thus
     HOBACGEN is particularly useful for comparative genomics, phylo-
     geny and molecular evolution studies on bacteria.

     The  database contains all sequences of bacteria (eubacteria and
     archeae)  and  yeast  taken  from SWISS-PROT + TrEMBL, with some
     annotation modifications. It contains also all the corresponding
     nucleotide  sequences  from  EMBL. Homologous proteins are clas-
     sified  into  families  and multiple alignments and phylogenetic
     trees are computed for each family.

     HOBACGEN  interface is based on a client/server architecture. To
     access  the  data the users only need to install client software
     on  their  computer. This program, written in Java, integrates a
     GUI  that allows users to easily access and visualize sequences,
     alignments and phylogenetic trees from the database.



                  Guy Perriere and Laurent Duret
                  Laboratoire de Biometrie, Genetique et
                  Biologie des Populations, URA CNRS 5558
                  Universite Claude Bernard - Lyon 1
                  43, bd. du 11 Novembre 1918
                  69622 Villeurbanne Cedex
                  France

                  Email: {perriere, duret}@biomserv.univ-lyon1.fr