Genetic-Epidemiological Studies of Complex Diseases CSHL

[CSHL Meetings & Course Office]

Cold Spring Harbor Course
Genetic-Epidemiological Studies of Complex Diseases
June 7 - 13, 2000
Instructors:
Neil Risch, Stanford University
Elizabeth Squires-Wheeler, Columbia University College of Physicians & 
Surgeons
This lecture course will consider the difficulties in studying the
genetic 
basis of complex disorders, such as diabetes, cardiovascular disease, 
cancer, Alzheimer's disease, schizophrenia and epilepsy, with a
particular 
emphasis on neuropsychiatric conditions. We will discuss 
genetic-epidemiologic study designs, including family, twin and adoption 
studies, as well as mode of inheritance analyses, and their role in
setting 
the framework for understanding the genetic and non-genetic components
of a 
disease. A major focus will be the identification of specific gene
effects 
using both linkage and association analysis. We will discuss the
efficiency 
and robustness of different designs for such analysis; further we will 
consider how evidence from genetic-epidemiologic studies informs both
the 
design and interpretation of molecular genetic studies. Recent
discoveries 
of genes for both Mendelian and non-Mendelian diseases will guide the 
discussion of the various methodologic issues.   We look forward to
seeing 
you at Cold Spring Harbor. 	


Apply online at http://www.cshl.org/meetings