Kevin Howe klh at
Mon May 22 14:00:35 EST 2000

                ANNOUNCING PFAM RELEASE 5.3

Pfam is a collection of protein domain family alignments which were
constructed semi-automatically using profile hidden Markov models.
Pfam families contain functional annotation and cross-references to
other databases.  Query sequences can be searched against the Pfam
library of profile hidden Markov models at the web sites below.

Pfam 5.3 contains 2216 families.  66% of proteins in SWISSPROT 38
and TrEMBL 11 have at least one match to a Pfam family.

For interactive access and searching see URLs


The release is also available in flat file by anonymous ftp:


The Pfam HMM library is compatible with HMMER2 software, available

and also the Wise2 software, available from


The Pfam consortium

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