Antibody design online: reduce cross-reactions
czhu at changbioscience.com
Mon Jul 1 03:31:16 EST 2002
Abie Pro 3.0 is for peptide antibody design. Proteomes of each species
has a unique pattern of over-represented short amino acid sequences.
For example, GSGS is present in the mouse proteome for thousands of
times and in thousands of proteins. These over-represented sequences
cause problems for peptide antibody design. If present in a peptide
used for raising an antibody, they may induce an antibody that
cross-reacts with a large number of unwanted proteins. By selecting a
peptide with few over-represented sequences, a user will have a better
success rate in raising an antibody with low background. For a test,
Comments and suggestions will be appreciated. Thanks.
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