[Bionews] Tissue Engineering
PMasi at liebertpub.com
Thu Aug 3 10:16:44 EST 2006
For immediate release
Contact: Vicki Cohn, Mary Ann Liebert, Inc., (914) 740-2100, ext. 2156, vcohn at liebertpub.com
Repair of Damaged Vocal Tissue Using Tissue Engineering
New Rochelle, NY, August 3, 2006-Injured vocal tissue can cause hoarseness and loss of vocal control-problems affecting 3%-9% of Americans each year. A new repair strategy described in the August 2006 issue (Volume 12, Number 8) of Tissue Engineering shows promise for regenerating damaged vocal fold tissue by injecting Carbylan(tm)-GSX, a chemically modified hyaluronic acid-gelatin hydrogel. Tissue Engineering is a peer-reviewed journal published by Mary Ann Liebert, Inc. (www.liebertpub.com) The paper is available free online at www.liebertpub.com/ten
Suzy Duflo, MD, Susan Thibeault, PhD, Wenhua Li, MSc, Xiao Zheng Shu, PhD, and Glenn Prestwich, PhD, describe their efforts to determine the optimal composition of a hyaluronic acid-gelatin extracellular matrix (ECM) that would promote wound repair and stimulate tissue regeneration in a paper entitled, "Vocal Fold Tissue Repair in Vivo Using a Synthetic Extracellular Matrix."
Using a rabbit model of vocal fold wound healing, the authors, from the Fédération d'Otorhinolaryngology, (Marseille, France) and the University of Utah School of Medicine (Salt Lake City), compared the results obtained with Carbylan-SX, a derivative of hyaluronic acid mixed with 2.5, 5, 10, or 20% gelatin. The Carbylan with 5% gelatin showed the most promise as a scaffold material for vocal tissue regeneration. Injection of the synthetic ECM resulted in improved tissue elasticity and viscosity, desired biomechanical properties that aid in vocal fold wound healing.
"The breadth of applications in the world of tissue engineering continues to grow. Vocal cord function requires a unique combination of elasticity and strength-features that are amenable to control using emerging scaffold materials, as outlined in the paper by Duflo, et al." says Peter C. Johnson, M.D., President and CEO of Scintellix, LLC and Co-Editor in Chief of Tissue Engineering.
Tissue Engineering is an authoritative peer-reviewed journal published monthly in print and online that brings together scientific and medical experts in the fields of biomedical engineering, materials science, molecular and cellular biology, and genetic engineering. Tissue Engineering is the official journal of the Tissue Engineering & Regenerative Medicine International Society (TERMIS). Tables of contents and a free sample issue may be viewed online at www.liebertpub.com/ten
Mary Ann Liebert, Inc., is a privately held, fully integrated media company known for establishing authoritative peer-reviewed journals in many promising areas of science and biomedical research, including Human Gene Therapy, Stem Cells and Development, and Cloning and Stem Cells. Its biotechnology trade magazine, Genetic Engineering News (GEN), was the first in its field and is today the industry's most widely read publication worldwide. A complete list of the firm's 60 journals, books, and newsmagazines is available at www.liebertpub.com <http://www.liebertpub.com/>
Mary Ann Liebert, Inc. 140 Huguenot St., New Rochelle, NY 10801-5215 www.liebertpub.com <http://www.liebertpub.com/>
Phone: (914) 740-2100 (800) M-LIEBERT Fax: (914) 740-2101
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