sendall at dxpt01.cern.ch (Mike Sendall) writes:
I recently subscribed to this newsgroup, but I understand that there
was an email list before this, that I hadn't subscribed to (maybe it
was btk-mca). Could anyone tell me where there is an archive of that
mailing list?
prm at aber.ac.uk (Pedro Mendes) writes:
I hear that John Woods has the archive of the email list (btk-mca) stored in
the FTP server darwin.brookes.ac.uk, which also contains software for
simulation and analysis of metabolic regulation. Have a look in there, I'm not
sure if the archive is there on-line (John, can you confirm this?)
There isn't one yet, but we should start one (if wasn't too busy writing my
thesis I'd volunteer. As it is, I can't even think about it!!)
-----
Darwin is up! But it is called bmsdarwin.brookes.ac.uk,
161.73.104.10. Please feel free to log on and look round at any time.
The mailing list archive isn't yet up to date (I should be writing my
thesis too!) but it will be by the end of this week. Nevertheless,
there should be enough there to start you off.
As for the FAQ, it's going to have to be a joint effort. I'm starting
it off (officially :-) as of now.
**********************************************************************
bionet.metabolic-reg/BTK-MCA FAQ
Discussion draft. Please treat this document as the straw man it is
intended to be --- alterations and disccussion are urgently requested.
NB: I'm half-serious about the last sentence in point four. If there
are enough objections I'll remove it, but I'd really rather not get
into philosophical nitpicking that might discourage future readers who
are more interested in biochemistry than semantics. Not yet, anyway.
**********************************************************************
Section 1 --- about the newsgroup.
1.0) What is a FAQ?
An FAQ is a listing of Frequently Asked Questions. It is
intended to prevent repeated discussion of certain points on
the newsgroup and to give newcomers a brief introduction to
the scope of the group.
1.1) Where can I get FAQs?
There is a machine around called rtfm.*.* (somebody fill in
the blanks please) which stocks the FAQs for most newsgroups.
But the one for this group isn't ready for inclusion yet, so
just watch for its sporadic posting in this group.
1.2) What is bionet.metabolig-reg for?
Discussion of topics concerning metabolic regulation,
particularly from a quantitive point of view. I quote form
our initial charter:
``The International Study Group for BioThermoKinetics is an informal
group devoted to the quantitative understanding of the kinetics,
thermodynamics and control of biological processes at the cellular
level ... BTK meetings are aimed at providing a forum for a vivid
exchange of ideas between experimenters with a keen eye for
quantitative aspects, theoreticians with a keen eye for the
experimental practice and those in between.'' (Preface, Programme for
5th BTK meeting) This mailing list [and newsgroup] is intended to
provide not only some continuity between the biennial meetings but
also to serve to propagate interest in the subjects covered. Informal
participation is welcomed from all fields (and at all levels), and it
is particularly, but not exclusively, encouraged in the domain of
Metabolic Control Analysis --- the investigation of control in
biological systems.
1.3) What is BioThermoKinetics?
I'm not really sure :-) Suggestions welcome. Hans?
1.4) What is Metabolic Control Analysis?
Metabolic Control Analysis is the investigation into the mechanism
and distribution of control in metabolic, and conceivably other
biochemical systems. Using certain theorems, it is possible
to relate the measurable *in vitro* properties of enzymes
and their effectors to the *in vivo* properties which
concern us. As far as I am concerned, Metabolic Control
Analysis is the activity thus described, whilst Metabolic
Control Theory is the theoretical foundation on which it
rests. (Very much like systems analysis is something done by
people who analyse systems, and systems theory is something
done by people who think more about systems analysis itself
than the analysis of particular systems). Mileage differs
greatly in the newsgroup about this issue, and now I've had my
say, further discussion is discouraged. :-)
1.5) What should I read?
Try Fell, D. (1992) Biochem J. 286:313-330 for a recent review
and the references therein for more introductory material.
1.6) What should I ask?
Anything related to metabolic regulation. Give us a try.
Section 2 --- about MCT
2.1) What are the fundamental theorems of MCA?
2.2) What is the importance of the theorems in 2.1?
Section 3 --- about MCA
3.1) How do I make my yeast glycolize faster? Pump up the PFK?
3.2) Is rubisco rate-limiting?
**********************************************************************
Ok, somebody else can get a word in edgeways now. Let's try and get
the FAQ to 1000 lines of good quality info. Everything in this draft
is up for graps, including section layout and question wording. What
do people think?
... John Woods
--
"
Forsan et haec olim meminisse iuvabit (Virgil)
[approx] Tr: The time may come when we will look back on these days and laugh
"
