IUBio

proceedings BTK 1992

unknown at dl.ac.uk unknown at dl.ac.uk
Mon Jan 17 09:30:09 EST 1994


Dear Biothermokineticists,

I did overhear Pedro Mendes' inquiry concerning the proceedings. Recently, 
Plenum Press (New York and London) sent me a sales bulletin announcing the
book "Modern Trends in Biothermokinetics" (proceedings of the Fifth 
International Meeting held in Bordeaux-Bombannes, France, September 23-26, 
1992, eds S. Schuster, M. Rigoulet, R. Ouhabi and J.-P. Mazat) for 
January/February 1994. The ISBN no. is 0-306-44579-4. We have expected it to 
appear earlier, but it's partly our fault as well (I changed position two 
times during the period of edition).

Attached goes the table of contents with the final page numbers.

Greetings,

Stefan=Schuster @ rz.hu-berlin.de


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CONTENTS



I. Thermodynamics and Kinetics of Transport Processes and Biological Energy Transduction
	                         1

Frontiers in the Mathematical Description of "Biothermokinetic" Phenomena
	G. R. Welch		3-6

Monitoring a Heterogeneous Coupled System Using Soluble and Biologically Localized Firefly 
Luciferase as a Probe for Bulk and Local ATP
	C. Aflalo               7-10

Control of Cytochrome C Oxidase: Kinetic, Thermodynamic or Allosteric?
	P. Nicholls            11-16

Mechanism of Bupivacaine Uncoupling in Rat Heart Mitochondria
	F. Sztark, P. Schonfeld, P. Dabadie and J.-P. Mazat		17-22			
	
Mosaic Non-Equilibrium Thermodynamics as a Tool in the Study of Oxidative 
Phosphorylation
	B.H. Groen, J.A. Berden and K. van Dam	23-26

The Redox State of Cytochromes as a New Tool to Assess the Thermodynamic State of 
Mitochondria
	S. Luvisetto, I. Schmehl, M. Canton and G. F. Azzone	27-32

Thermodynamic Response Paradigm and its Application to Oxidative Phosphorylation
	B. Korzeniewski and W. Froncisz	33-38

A Model Study on the Interrelation between the Transmembrane Potential and pH Difference 
across the Mitochondrial Inner Membrane
	S. Schuster and J.-P. Mazat	39-44

Comparison of Retinal-Based and Chlorophyll-Based Photosynthesis: A Biothermokinetic 
Description of Photochemical Reaction Centers
	K.J. Hellingwerf, W. Crielaard and H.V. Westerhoff	45-52

Regulation of Energy Flux of Yeast during Steady State and Oscillatory Growth
	R. Olz, K. Larsson, Ch. Larsson, E. Gnaiger and L. Gustafsson	53-60

Free-Energy Coupling Mediated by Dynamic Interactions between Membrane Proteins
	R.D. Astumian, B. Robertson and M. Bier	61-66

Characterization of Energy-Dependent Phosphate Uptake by Blue-Green Alga Anacystis 
nidulans: Adaptation to External Phosphate Levels Obeys a Linear Flow-Force Relation
	G. Falkner, F. Wagner and R. Falkner	67-70

Brownian Dynamics Simulation of Charged Membrane Components. Implications for 
their Lateral Distribution and Voltage Dependence of Ion Transport through Membranes
	D. Walther, P. Kuzmin and E. Donath 	71-76

Evolutionary Strategies and the Optimization of Carrier Models
	J. Lenz and M. Hofer	77-81


II. Modeling of Cell Processes with Applications to Biotechnology and 
     Medicine	83

Mathematical Model of the Creatine Kinase Reaction Coupled to Adenine Nucleotide 
Translocation and Oxidative Phosphorylation
	M.K. Aliev and V.A. Saks	85-92

Critical Regulation of Multienzyme Complexes: A Kinetic Model for the Mammalian Pyruvate 
Dehydrogenase Complex
	B.N. Goldstein and V.A. Selivanov	93-96

The Analysis of Flux in Substrate Cycles
	D.A. Fell	97-101

Estimation of Enzymatic Flux Rates from Kinetic Isotope Experiments
	H.-G. Holzhutter and A. Schwendel	103-107

When Going Backwards Means Progress: On the Solution of Biochemical Inverse Problems 
Using Artificial Neural Networks
	D.B. Kell, Ch.L. Davey, R. Goodacre and H.M. Sauro	109-114

Quality Assessment of a Metabolic Model and Systems Analysis of Citric Acid 
Production by Aspergillus niger
	N. Torres, C. Regalado, A. Sorribas and M. Cascante	115-124

Steady-State Measurements and Identifiability of Regulatory Patterns in Metabolic 
Studies
	A. Sorribas and M. Cascante	125-131

A Biochemical "NAND" Gate and Assorted Circuits
	H.M. Sauro	133-140

Dynamic Modeling of Cell, Substrate, and Product Concentrations and pH in E. coli-
Containing Agar Membranes
	J. Lefebvre and J.-C. Vincent          141-147

The Interpretation of Flow Cytometry Profiles in Terms of Gene Dosage and Gene Expression
	W.G. Bardsley and E.K. Kyprianou	149-153


Invention of a Useful Transcriptional Regulation System Using Mechanistic 
Mathematical Modeling
	W. Chen, S.-B. Lee, P. Kallio and J.E. Bailey	155-158

Tumor Progression and Catastrophe Theory
	H. Daams, S. Cortassa, M. A. Aon and H.V. Westerhoff	159-166

Biochemical Neuron: Application to Neural Network Studies and Practical 
Implementation of Device
	M. Okamoto, Y. Maki and T. Sekiguchi	167-172

Example of the Use of Computers to Study the Variability of Seed Development of a Parasitic 
Weed, Striga hermonthica (Del.) Benth. (Scrophulariaceae), after Treatment 
by Herbicide
	J. Pare	173-176


III. Metabolic Control Theory: New Developments and Applications	177

Responses of Metabolic Systems to Large Changes in Enzyme Activities
	J.R. Small and H. Kacser	179-185

An Extension of Metabolic Control Analysis to Larger Parameter Perturbations by Inclusion of 
Second-Order Effects
	T. Hofer and R. Heinrich	187-192

A Control Analysis of Metabolic Regulation
	J.-H.S. Hofmeyr and A. Cornish-Bowden	193-198

Regulation and Homeostasis in Metabolic Control Theory: Interplay between 
Fluctuations of Variables and Parameter Changes
	D. Kahn and H.V. Westerhoff	199-204

Sum of the Flux Control Coefficients: What is it Equal to in Different Systems?
	B.N. Kholodenko and H.V. Westerhoff	205-210

Control Analysis of Metabolic Channeling
	P. Mendes and D.B. Kell	211-216

Path Analysis in General Control Theory
	G. Meszena	217-224

Phenomenological Kinetics and the Top-Down Approach to Metabolic Control Analysis
	G.C. Brown	225-228

A Modular Approach to the Description of the Control of Connected Metabolic Systems
	S. Schuster, D. Kahn and H.V. Westerhoff	229-235

Control Analysis of Isoenzymic Pathways: Application of Directed Graphs and 
Electrical Analogs
	A.K. Sen	237-242


Derivation of a General Matrix Method for the Calculation of Control Coefficients
	M. Ehlde and G. Zacchi	243-252

Internal Regulation. The C.E=I=E.C Square-Matrix Method Illustrated for a Simple Case of a 
Complex Pathway
	A.A. van der Gugten and H.V. Westerhoff	253-262

Multiplicity of Control
	H.V. Westerhoff, P.R. Jensen, A.A. van der Gugten, D. Kahn, 
	B.N. Kholodenko, S. Schuster, N. Oldenburg, K. van Dam 
	and W.C. van Heeswijk	263-268

Control of Threonine Biosynthesis in E. coli
	B. Rais, R. Heinrich, M. Malgat and J.-P. Mazat	269-274

Control Coefficients in Cellular Cation Homeostasis: A Model Analysis
	J. Siegenbeek van Heukelom	275-279


IV. Control and Regulation of Oxidative Phosphorylation	281

Experimental Discrimination between Proton Leak across the Mitochondrial Membrane and 
Slip in the Proton Pumps of the Electron Transport Chain
	M.D. Brand and Ph. Diolez	283-286

Does Redox Slip Contribute Significantly to Mitochondrial Respiration?
	K.D. Garlid, C. Semrad and V. Zinchenko	287-293

Mechanistic Stoichiometry of Yeast Mitochondrial Oxidative Phosphorylation: 
A Behavior of Working Engine	
	V. Fitton, M. Rigoulet and B. Guerin	295-299

Mitochondrial Creatine Kinase: Biothermokinetics of the Reaction and its Role in the 
Regulation of Energy Fluxes in Muscle Cells in vivo
	V.A. Saks, G.V. Elizarova, Yu. O. Belikova, E.V. Vasileva, 
	A.V. Kuznetsov, L. Petrova, N.A. Perov and F.N. Gellerich	301-312

Effect of Macromolecules on ADP-Channeling into Mitochondria
	F.N. Gellerich, M. Wagner, M. Kapischke and D. Brdiczka	         313-318

Control of ATP Flux in Rat Muscle Mitochondria
	S. Jouaville, F. Ichas, T. Letellier, M. Malgat and J.-P. Mazat	319-325

Control of Respiration of Mitochondria from Euglena gracilis Determined by Means of 
Metabolic Control Analysis: Comparison of Oxidation of Matrix- and Cytosolic NADH
	A. Kesseler, S. Kisteneich and K. Brinkmann	327-332

Top Down Metabolic Control Analysis of Oxidative Phosphorylation at Different Rates in 
Potato Tuber Mitochondria
	A. Kesseler, Ph. Diolez, K. Brinkmann and M.D. Brand	333-338

The Influence of Phosphate on the Distribution of Flux Control among the Enzymes of 
Oxidative Phosphorylation in Rat Skeletal Muscle Mitochondria
	W.S. Kunz, E. Wisniewski and F.N. Gellerich	339-342

The Molecular Basis of Threshold Effects Observed in Mitochondrial Diseases
	J.-P. Mazat, T. Letellier and M. Malgat	343-346

Control of Respiration in Heart Mitochondria. Comparative Study of Oxidation of Succinate 
and NAD-Dependent Substrates
	V. Mildaziene, V. Borutaite, Z. Katiliute, R. Petroliunaite, 
	L. Ivanoviene, A. Toleikis and B.N. Kholodenko	347-350

Mechanisms of the Effects of Hypothyroidism and Hyperthyroidism in Rats on 
Respiration Rate in Isolated Hepatocytes
	M.-E. Harper and M.D. Brand	351-356

Substrate and Calcium Dependence of the Pyridine Nucleotide and Flavine Redox State 
in Rat Heart Mitochondria Respiring at Different Metabolic States
	R.C. Scaduto, Jr. and A.V. Panov	357-365


V. Investigation of Cell Processes	367

Modification of Mitochondrial Metabolism by Amino Acid-Induced Cell Swelling
	P. Espie, M. Rigoulet and B. Guerin	     369-376

Estimation of the Mechanism of Peptide Binding to HLA Class II Molecules	
	E. Furuichi, N. Kamikawaji, T. Sasazuki and S. Kuhara	377-381

Shift of a Peptide Bond Equilibrium towards Synthesis Catalyzed by alpha-Chymotrypsin
	B. Deschrevel and J.-C. Vincent	383-390

Modulation of Cellular Energy State and DNA Supercoiling in E. coli
	P.R. Jensen, N. Oldenburg, B. Petra, 
	O. Michelsen and H.V. Westerhoff	  391-396

Cascade Control of Ammonia Assimilation
	W.C. van Heeswijk, H.V. Westerhoff and D. Kahn	397-399

Photovoltage Measurements as a Probe of Light Distribution and Ion Movements around 
Photosynthetic Apparatus
	G. Meszena and H.V. Westerhoff	  401-406

Neural Networks Applied to Cell Signaling and Chemical Communication in Cell Networks
	J.A. Prideaux, J.L. Ware, A.M. Clarke and D.C. Mikulecky  	407-411

Synchronization of Glycolytic Oscillations in Intact Yeast Cells
	P. Richard, B. Teusink, H.V. Westerhoff and K. van Dam	413-416

Control in Electrophysiology and Intracellular Signal Transduction
	H. van Mil and J. Siegenbeek van Heukelom	     417-422

Structure-Function Relationship of Magainins. Studies in Liposomal Model Systems
	A. Vaz Gomes, A. de Waal, J.A. Berden and H.V. Westerhoff 	423-425

The Communication between the Mitochondrial and Cytosolic Branches of Energy Metabolism
	F. Laterveer, F. van Dorsten, A. van der Toorn and K. Nicolay 	427-433

Calculation of Metabolic Fluxes by Mathematical Modeling of Carbon-13 Distribution 
in Metabolites. I. Presentation of the Mathematical Model
	R. Schuster, J.-C. Portais, F. Garderet, 
	M. Merle, J.-P. Mazat and P. Canioni	435-442

Calculation of Metabolic Fluxes by Mathematical Modeling of Carbon-13 Distribution 
in Metabolites. II. Application to the Study of C6 Cell Metabolism
	J.-C. Portais, R. Schuster, F. Garderet, 
	M. Merle, J.-P. Mazat and P. Canioni	443-447


VI. Computer Programs for Modeling Metabolic Systems	449

MLAB: An Advanced System for Mathematical and Statistical Modeling
	G.D. Knott	451-454

SIMFIT - A Computer Package for Simulation, Curve Fitting and Statistical Analysis Using 
Life Science Models
	W.G. Bardsley 	455-458

Optimal Design for Model Discrimination. Choosing the Best Spacing and Density of Design 
Points
	W.G. Bardsley and E.M. Melikhova	    459-462 

GEPASI: A User Oriented Metabolic Simulator
	P. Mendes	463-466

Object Oriented Simulation of Metabolic Processes
	H.J. Stoffers, B. van Stigt, P. Richard, A.A. van der Gugten, 
	H.V. Westerhoff and G.J.F. Blommestijn	467-472

MetaCon - A Computer Program for the Algebraic Evaluation of Control Coefficients 
of Metabolic Networks
	S. Thomas and D.A. Fell	473-478


VII. Oenological Epilogue	479

Champagne in Holland: An Experiment in Oenology
	H. Daams and A. Daams-Moussault	481-483


Index			485




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