IUBio

amino acid metab.

Stephen Misener MISENERS at QUCDN.QueensU.CA
Fri Jun 17 17:11:48 EST 1994


In article <2ts7va$fdo at babyblue.cs.yale.edu>, johnk at loglady.ninds.nih.gov (John
Kuszewski) says:
>|>
>
>Both your proposals are complete crap.  "Essential" amino acids are those
>that people can't synthesize for themselves, but plants can.  We don't
>bother having synthetic mechanisms for all the AAs for the same reason
>that we don't bother having a synthetic mechanism for glucose (from CO2,
>that is)--it's perfectly easy just to eat plants, letting them do all
>the work.
>
>
>--
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>                                   --  /\  //  /--
>                                   ||  ||  /  /||
>                                   ||  || /  / ||
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>John Kuszewski                     ||  |/  /|  ||
>johnk at spasm.niddk.nih.gov          ||  /  /||  ||
>                                   \/ /  / ||  \/
>that's MISTER protein G to you!     |/__/|      |
>                                      /_________|


Well...I am aware of the fact that we are unable to synthesize essential amino
acids...hence the name.  But I think you missed the point.  I am trying to
come up with an explanation for why we can synthesize *any* amino acids given
the fact that they occur in our diet at adequate levels (for the most part).
I argue that we have maintained these pathways because these amino acids play
some important regulatory role *besides* protein synthesis.  For example
arginine biosynthesis in the urea cycle.  I don't think we can lose this
biosynthetic pathway.  What I am *most* interested in is people's opinion
on whether/not all essential amino acids must play some important role, and
that all non-essential ones have no role besides protein synthesis.  Even
I think this may be too simplistic a view...but I can think of no examples
of essential amino acids having some important biological role.

Stephen Misener
Queen's U Biology
miseners at QUCDN.QueensU.CA



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