IUBio

Syndrome X, diabetes and cortisol

Paul M. Schlosser schlosser at ciit.org
Fri Feb 9 10:32:33 EST 1996


In <Pine.SUN.3.91.960130185034.5649A-100000 at molly>,
Gary Wilson <gwilson at molly.hsc.unt.edu> writes:

[snip]
>There is also the Syndrome X that is studied in Europe by Per Bjorntorp
>at the University of Goteburg in Sweden which is also called the
>metabolic syndrome. The European version includes the factor of stress in
>the development of the syndrome. Stress causes an increase in cortisol
>levels and according to Bjorntorp constant stress with no relief can
>cause chronic high levels of cortisol which in turn leads to insulin
>resistance and then to hypertension and diabetes.
>
>Another symptom of this Syndrome X appears to be a lowering of
                                                    ^^^^^^^^^^^
>testosterone levels which leads to a lowering of the synthesis of protein
 ^^^^^^^^^^^^^^^^^^^
>in muscle tissues.

[snip]

Many of you may be aware of recent attention to apparent drops in
sperm counts over the last 40-50 years.  (As more data is evaluated,
it looks as if these drops are real.)  This makes me wonder if this
factor is related.  Any idea how wide-spread is syndrome X?  From
anecdotal/personal evidence, it sure seems that high levels of stress
are quite widespread.

Paul S.

~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
Paul M. Schlosser, Ph.D.
Chemical Industry Institute of Toxicology (CIIT)
P.O. Box 12137
6 Davis Drive (not needed for regular mail)
Research Triangle Park, NC  27709
schlosser at ciit.org
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