> >Are there any references out there for multifunctional enzymes?
> >
> >Thanks! Please email to: pollack.1 at osu.edu>> Cytochrome P450s are typically multi-functional (act on multiple
> substrates)? Is that the sort of thing you are looking for?
delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine synthetase is a non
ribosomal peptide synthetase forming ACV tripeptide in the Cephalosporin
and Penicillin biosynthetic pathways.
Reviews exist on polyketide syntheses, which are enzymes with multiple
functionalities on the same protein. Many groups are working on
restructuring such multifunctional enzymes to produce novel polyketides.
Anurag
______________________________________________________________________________
___ ___ Anurag Khetan
[ ] [ ] Dept. of Chem. Engg. & Materials Sc.
/ \ / \ University of Minnesota
/ /\ \ / /\ \ Minneapolis MN 55455 USA
[___] [___] [___] e-mail: khetan at cems.umn.edu
______________________________________________________________________________
