On 6 Jun 96 at 14:51, Achim Recktenwald wrote:
> I am looking for a table listing the normal concentrations of typical cell
> metabolites, e.g., amino acids, NAD, ATP, ions, sugars, major proteins, etc.
> A few years back I once stumbled over such a table. Unfortunately, I did not make a
> copy. The only entries I can remember:
> typical cell protein concentration 100-300mg/mL
> acetate ion 0.2 - 0.25 M
The following two papers have some tables with concentrations of
metabolites and enzymes
Albe, K.R., Butler, M.H. and Wright, B.E. (1990), "Cellular
concentrations of enzymes and their substrates.", J.Theor.Biol. 143,
163-195
Sols, A. (1970) Curr.Top.Cel.Reg. 2, 227-?
(sorry about the last one not being complete, but I've got the paper at
home)
The major problem here is what you consider a typical cell to be. A pig
neuron (which type?) ? A human hepatocyte? a tetrahymenas cell? a
blue-gree algae? All of these will have very different metabolite
concentrations between each other (some metabolites are only present in
some of them). Even worse, each cell will perhaps have many different
concentrations throughout its life cycle (or circadian rhythm).
Pedro Mendes Inst. Biological Sciences
prm at aber.ac.uk (home: pedro at enzyme.demon.co.uk) Univ. Wales, Aberystwyth,
http://gepasi.dbs.aber.ac.uk/pedro/prmhome.htm Dyfed SY23 3DA, U.K.
PGP mail welcome! (public key on demand) FAX: +44 (0)1970 622350
