I have only recently learned of metabolic control analysis but I find it
very interesting. Being a pharmacologist by training I was wondering if
anybody has considered signal transduction pathways as a special case of
metabolic control. These pathways are very tightly controlled and capable
of inducing massive changes in the concentration of a single metabolite.
Can this be accomplished simply by regulating an enzyme with a control
coefficient very close to 1, or is there more to the story. If not, is
there something to be learned about more subtle changes in metabolic
pathways by studying this relatively simple case. Any thoughts?
Daniel M. Sullivan, Ph.D.
NEI/NIH - Lab of Immunology
Section on Ocular Gene Therapy
Bldg 10 Room 10N202
9000 Rockville Pk.
