In article <3366A28D.5953 at ix.netcom.com>, Bob Phair says...
>>I probably don't yet completely understand the terminology, but if a
>flux control coefficient is the same as Kacser's Sensitivity
>coefficient, Z, or even if it's the same as his response, R, (=Z*kappa),
>then it seems to me Kacser, himself, provided the required proof.
Yes, the flux-control coefficient is the same as Kacser's Z sensitivity
coefficient. The terminology was standardised in
Burns, J.A., Cornish-Bowden, A., Groen, A.K., Heinrich, R., Kacser, H.,
Porteous, J.W., Rapoport, S.M., Rapoport T.A., Stucki, J.W., Tager, J.M.,
Wanders, R.J.A. & Westerhoff, H.V. (1985), Control of metabolic systems.
Trends Biochem. Sci. 10, 16.
>I've only been part of this newsgroup for a short while, but I already
>feel I should have been here years ago. Perhaps someone will educate me
>still further, but I found Kacser eye-opening and profound.
Bob, you are needed here! MCA has been slow penetrating the Us but I think
we have now gone past the point of no return. See my "MCA Web" at
http://gepasi.dbs.aber.ac.uk/metab/mca_refs.htm
This is not a complete reference but maybe will help you with the
terminology. The page of references may especially be of interest to you.
Athel Cornish-Bowden also has web pages on MCA but his site seems to be
down. The URLs for this are
http://ir2lcb.cnrs-mrs.fr/lcbpage/athel/fek10/mcai.htmlhttp://ir2lcb.cnrs-mrs.fr/lcbpage/athel/mcafaq.html
Phil Butler from UMIST lectures a course on MCA and he's also got MCA on his
web pages:
http://www.bi.umist.ac.uk/courses/2IRM/MCA/default.htm
>Can anyone tell me something about the intellectual lineage of people
>working in this field today? You all seem to know each other well; did
>you all train in the same labs? Thanks.
We know each other from several MCA related conferences. For a while there
was a sense of frustration as it seemed the US researchers were not
attracted to this analytical formalism. This seems to be changing now (and I
hope you'll help this trend)
--
Pedro Mendes | Inst. Biological Sciences
prm at aber.ac.uk (home: pedro at enzyme.demon.co.uk) | Univ. Wales, Aberystwyth,
http://gepasi.dbs.aber.ac.uk/pedro/prmhome.htm | Ceredigion SY23 3DA, U.K.
Author of the biochemical kinetics simulator Gepasi
http://gepasi.dbs.aber.ac.uk/softw/Gepasi.html
