IUBio

Biochemistry/metabolic regulation question

Albrecht Roscher ar at drfmc.ceng.cea.fr
Wed Feb 26 05:51:30 EST 1997


To my understanding, the reaction should be read the other way round:

1. Enz-OH + Glucose-1,6-bisPhoshate + free Glucose-6-Phosphate 
   to Enz-OH + Glucose-1,6-bisPhoshate + bound Glucose-6-Phosphate

2. The phosphate group 6 from Glucose-1,6-bisPhoshate is transferred to
position    1 of Glucose-6-Phosphate , probably via an Enz-O-Phosphate
intermediate,      
   resulting in Enz-OH + Glucose-1,6-bisPhoshate + bound Glucose-1-Phosphate

3. Glucose-1-Phosphate is released giving 
   Enz-OH + Glucose-1,6-bisPhoshate + free Glucose-1-Phosphate

The net reaction is:

Glucose-6-phosphate  to  Glucose-1-phosphate.

This reaction is fully reversible. The decision of direction depends on the
bound monophosphate.

One reference, probably not the best, is C. B. Post et al., Biochemistry 28, p.
548 (1989)

Albrecht




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