I had avoided this, but was encouraged by Athel in an email about something
else to put my $0.02 in:
> >PPS - I haven't joined the discussion about log control coeffs, but
> >believe me (and here I unusually side with Martin Brand): no UK
> >undergraduates know what logs are or what d ln means, dy/y upon dx/x
> >is just about intelligible for them, and to be preferred for didactic
> >purposes.
That of course was biology undergraduates, and I would add that the 'truth'
can/should of course be used in the simulations, but can be more or less
hidden from people who may, if they are up to it, be exposed gently via the
Help file.
Finally (despite flak that may appear) I personally have come to prefer true
simulations, of which classical MCA may be seen as a subset. This is because
of the 'large changes' issues surrounding biotechnology, metabolic pathway
engineering and the like, where we recognise that large changes in individual
or even several enzymes lead to a priori quite unpredictable effects on
fluxes.
All the best,
Douglas.
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*Douglas B. Kell Phone: +44 1970 622334 *
*Edward Llwyd Building Fax: +44 1970 622354 *
*Institute of Biological Sciences *
*University of Wales, Email: dbk at aber.ac.uk *
*Aberystwyth SY23 3DA, U.K. http://gepasi.dbs.aber.ac.uk/home.htm *
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