Andrei Zhukov (Andrei.Zhukov at imm.ki.se) wrote:
: Does anybody know how exactly cycloheximide inhibits protein synthesis?
: Which enzyme or whatever does it act upon? I would very much appreciate
: an answer by e-mail and, if possible, some reference(s).
There may be several mechanisms involved: heres are 2 refs. that may offer
a less common (forgotten?) perspective:
Horgen and Griffin (1971): Specific inhibitors of the three RNA
polymerases from the aquatic fungus Blastocladiella emersonii. PNAS (USA)
68: 338-341.
Timberlake and Griffin (1974) Differential effects of cycloheximide and
other inhibitors of protein synthesis on in vivo ribosomal RNA synthesis
in Achlya bisexualis. Biochimica et Biophysica Acta 353: 248-252.
Vik Prabhu
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Department of Biology
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