In article <3461c953.0 at news.ic.sunysb.edu>, ingnang at life.cc.sunysb.edu
says...
>Interesting. However, both example cited are mammalian cells. I wonder
>how universial is the conclusion that the control of glycolysis is
>distributed among the kinases in the pathway. Anyone knows of other
>examples? Or maybe we can ask the question the other way round. How
>much do we have to tweak the system so that the control is no longer
>distributed among the kinases?
It would be sufficient to reduce the concentration of any other enzyme of
the pathway by a large amount (i.e. such that its limiting rate is
smaller than those of all the other enzymes). This is only one way of
redistributing the control, almost surely there are many more ways of
doing so. Due to the conservation of several moieties (adenilates,
phosphate, NAD, etc.) it is possible that the reduction in activity may
have to be extremely large... I guess the best way would be to try this
by simulation, perhaps Michael could do it.
--
Pedro Mendes
home: pedro at enzyme.demon.co.uk , work: prm at aber.ac.uk | Aberystwyth,
http://www.enzyme.demon.co.uk/pedro.html | Wales, U.K.
Author of GEPASI, a biochemical kinetics simulator | European Union
