Ing-Nang Wang wrote:
>Interesting. However, both example cited are mammalian cells. I wonder how universial is the conclusion that the control of glycolysis is distributed among the kinases in the pathway. Anyone knows of other examples?
In her paper at the BTK last year Barbara Bakker reported data for the
control of glycolysis in the bloodstream form of Trypanosoma brucei (pp.
136-142 in the Proceedings book). She found that if the activity of the
glucose transporter was at or below the wild-type in vivo level
essentially all the control was in glucose transport. When it was above
this level the control was distributed among several enzymes, NOT
including the usual kinases. The written account includes very little
numerical information about this, and the subsequent paper in J. Biol.
Chem. (272, 3207-3215 (1997)) gives none at all. However, I understand
that a paper analysing the control structure is on the way.
Athel
Email: athel at bigfoot.com
Home page: http://ir2lcb.cnrs-mrs.fr/lcbpage/athel/homepage.htm
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MCA chapter from my book:
http://ir2lcb.cnrs-mrs.fr/lcbpage/athel/mcai.htm
