Message from David Fell:
The message that follows was one I received from Dr Richard Veech, who
works at the National Institute for Alcoholism & Alcohol Abuse, Bethesda.
At my suggestion, he agreed to its being posted on this newsgroup. Reply
directly to him if interested - he is not a reader of this group.
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It strikes me that the reasons there are so few bottom up control strenght
studies is that the work required is simply to massive. It took us nearly
3 years and a number of people to produce the Kashiwaya paper. *
Nevertheless, one might derive useful information from such studies
involving other hormones, drugs, diets or genetic states.
Accordingly I have decided to attempt to automate the analyses the
metabolite and kinetic assays necessary to perform such analyses. Of
necessity this will also require a large amount of data manipulation,
quality controls and summarization. Standard biochemical training is
probably not what is required, but rather experience in physics and or
computer science and automation. We have available a fellowship which
initially pays $29,000/yr renewable for up to 5 years with increases.
Would you know any qualified candidates who might be interested in such a
project under these terms?
Dr Richard Veech
(Note: * J. Biol. Chem. 269, 25502-14 (1994))
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When I suggested he put it on this noticeboard, pointing out that there may
be readers who combined the biochemical and computing experties, he replied:
"I would appreciate you putting an announcement on your btk-mca newsgroup to
see if anyone is interested. We are at a point now where very few people
are capable of doing precise metabolite assays and evaluation of kinetic
constants. Our problem is to try to turn hand crafted expertese into
automated proceedures. That presents a number of engineering difficulties,
but I would think that, given the automated clinical machines available,
the bulk of the problem will involve transferring and manipulating data,
and building in checks on its reliability."
