On Jan 29, 10:15am, Athel Cornish-Bowden wrote:
> More important, there has *still* been no answer to Robert DiSilvestro's
> question about Cr isotopes. I'd answer it myself if I knew the answer, but
> unfortunately I don't, and can't think of anyone around me to ask. However,
> I find it hard to believe that there is *no one* who follows this group who
> has any idea.
>-- End of excerpt from Athel Cornish-Bowden
Perhaps we haven't answered because we don't understand his wording, viz. "cell
flow." Cr-51 and Fe-59 are often used to mark erythrocytes to measure residual
blood volume in tisues, as is I-131 for marking plasma. I presume the same
techniques could be used to measure blood perfusion rates. Is this what Robert
DiSilvestro means by cell flow? There are non-radioactive techniques also. One
is to use Evan's blue dye as a marker for plasma volume. A rigorous
mathematical analysis of indicator dye methods is:
KL Zierler, Circulation times and the theory of indicator-dilution methods for
determining blood flow and volume. In: Handbook of Physiology, Section 2:
Circulation, WF Hamilton & P Dow, eds. American Pysiological
Society:Washington, DC, 1962, p. 585-615.
--
Michael C. Kohn
Laboratory of Computational Biology and Risk Analysis
National Institute of Environmental Health Sciences
P.O. Box 12233, Mail Drop A3-06
Research Triangle Park, NC 27709-2233
Telephone:
919-541-4929 (voice)
919-541-1479 (fax)
e-mail:
kohn at valiant.niehs.nih.gov
WWW home page:
http://valiant.niehs.nih.gov
