Pedro Mendes wrote:
> I
> would say that the "level of aggregation suitable" (as Johann put it) can
> be either
>> (1) the reductionist elementary mechanistic level
> (2) the "wholistic" higher level of a group of enzymes (eg Paul Srere's
> metabolon) that are not kinetically independent
>> (2) follows Henrik Kacser's spirit of a descritption that does not require
> knowledge of mechanism, while (1) does not. It is interesting that so far
> (2) has not been much used for such systems.
Excuse the outsider again for interrupting the experts, but why
-wouldn't- we "require the knowledge of mechanism" for any biochemical
system? A -molecular- system should never be too complex to be
described successfully in elementary physico-chemical terms (mass action
law, diffusion, ...). What are the most important papers of Kacser's to
read, and are any of them available electronically?
-- Petr
_____________________________________________________________
Petr Kuzmic Ph.D. * BioKin Ltd. * Madison, WI 53708-8336, USA
pkuzmic at biokin.com * http://www.biokin.com * 608.256.1269 fax
