Dear Jannie,
It is true that various sensitivity coefficients can be obtained from
experiment as Henrik described quite early in the development of MCA,
but this is an emprical approach analogous to BSA. To link the control
to specific molecular steps still requires knowledge of the kinetic
mechanism. You've nicely described the relationship to simulation. My
belief is that only MCA (or an analogous sensitivity analysis) is
capable of providing lower-level insights.
Best wishes,
Michael
--
Michael C. Kohn
Laboratory of Computational Biology and Risk Analysis
National Institute of Environmental Health Sciences
P.O. Box 12233, Mail Drop A3-06
Research Triangle Park, NC 27709-2233
Telephone:
919-541-4929 (voice)
919-541-1479 (fax)
e-mail:
kohn at valiant.niehs.nih.gov
Web site:
http://valiant.niehs.nih.gov
