Dear Michael
> It is true that various sensitivity coefficients can be obtained from
> experiment as Henrik described quite early in the development of MCA, but
> this is an emprical approach analogous to BSA. To link the control to
> specific molecular steps still requires knowledge of the kinetic
> mechanism. You've nicely described the relationship to simulation. My
> belief is that only MCA (or an analogous sensitivity analysis) is capable
> of providing lower-level insights.
I agree with you 100%.
Jannie
Prof. Jannie Hofmeyr Tel: +27 21 808 3039
Dept. of Biochemistry Fax: +27 21 808 3022
University of Stellenbosch e-mail: jhsh at maties.sun.ac.za
Private Bag X1
Matieland 7602
Stellenbosch
South Africa
