Ronald Koder wrote:
> I recently saw a seminar in which someone spoke about the purine pathway
>> enzymes
> within the mitochondria. They were proposing that the enzymes formed
> big complexes
> with one other and that substrates channel from one enzyme to the next
> in the pathway
> without being released into solution. A good deal of their evidence was
>> of the negative
> variety: i.e. the rates of purine formation could not be described using
>> combinations of the
> rates constants determined for the individual enzymes.
>> This was a pretty cool idea, and evidently not a new one. As it seems
> to fall squarely
> within the boundaries of this news group, I decided to hear what other
> people on
> this list thought about it.
>> Ronald Koder
> The Institute for Biophysical Research on Macromolecular Assemblies
> The Johns Hopkins University
dude
check out Athel C-B
http://ir2lcb.cnrs-mrs.fr/~athel/homepage.htm
and metabolic control analysis
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Jeremy Murray MAIL: bmbjmm at bmb.leeds.ac.uk
Biochemistry & Molecular Biology TEL: +44 113 233 2591
Leeds University, LEEDS LS2 9JT FAX: +44 113 233 3167
http://www.smb.leeds.ac.uk/wwwsb/jez.html
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