IUBio

Fw: Garfinkel et al. (was Re: Is it Metabolic Control THEORY orM

Petr Kuzmic pkuzmic at biokin.com
Thu Aug 24 15:43:41 EST 2000



"S. Roy Caplan" wrote:
[...]
> Goldman, R., Silman, H.I., Caplan, S.R., Kedem, O. and Katchalski,
> E.  Papain membrane on a collodion matrix:  Preparation and enzymic
> behavior. Science 150, 758-760 (1965).
[...]
> I hope this is helpful!

It certainly is very helpful.  Thank you posting this mini-bibliography.

By the way, I wish someone with sufficient expertise in MCA (that is,
sufficient to *evaluate* the relevant literature) would take over where
Pedro Mendes left off in 1996 ...

	http://gepasi.dbs.aber.ac.uk/metab/mca_refs.htm

... and updated the online bibliography of MCA.  This kind of
bibliography would greatly benefit especially people *outside* the
BTK/MCA/MCT circle, which, to this observer, seems fairly closed at
times.  

When I say 'closed' I mean that a citation analysis of people active in
MCA *might* reveal that it's a cluster of authors referring to each
other's work. How else could we encounter that surprising piece of
correspondence, written by a junior researcher at Karolinska to Athel
sometime around the beginning of July:

>I work with PFK and am doing math models as well as molecular 
>biology with this protein. I know of no argument against 
>PFK as rate limiting step. If you have such an argument, 
>could you please explain. Even better, if this is a sound 
>argument, could I politely suggest publishing your idea in 
>Science or Nature. None of my collegues working in this 
>field are aware of this argument and such an argument 
>could potentially discredit many dozens of publications by 
>dozens of the most prominent biochemists in the world. 

Of course, saying "none of my colleagues working in this field are
aware..." shows a lack of experience of the kind that is to be expected
from a student, but it does mean that this doctoral "Aspirant" was not
directed by *either* of his two advisors (at Karolinska and at Boston
University) to read what he needs to read, namely

	http://ir2lcb.cnrs-mrs.fr/~athel/howler.htm
	http://ir2lcb.cnrs-mrs.fr/~athel/rls.htm

		- Petr

_____________________________________________________________________
P e t r   K u z m i c,  Ph.D.               mailto:pkuzmic at biokin.com
BioKin Ltd. * Software and Consulting           http://www.biokin.com






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