Thanks for the responses, even the couple of
very rude and unprofessional ones I got from
poorly informed would-be scientists who spend
more time discrediting good scientists than
doing real science.
It appears the reason for the confusion about
whether PFK is rate limiting depends on the
cell type. The nay sayers are citing yeast
and trypanosomes, while I am focused on mammalian
PFK studies, largely in skeletal muscle and
pancreatic beta cells. In the latter case, it
appears to remain valid that PFK is effectively
rate limiting.
It is sad that there were so many unprofessional
responses in this group and that nobody suggested
this might be the reason for these different
views. Instead, some of you chose to slander
very good biochemists, making this a poor excuse
for a scientific exchange.
I would like to thank Herbert M Sauro for his
kind and professional response.
Cheers,
Dominic
North 59 37' 30"
East 17 48' 10"
