I'm new to the MCA forum and will preface this by saying it's my first
post. I've had to read some papers lately not specifically related to my
work but interesting (to me at least) none the less. The papers are
those surrounding the original Randle et al hypothesis (and later ones
which, in a nutshell, implicated intracellular fatty acids as reducing glucose
oxidation. Recently, Wolfe and his colleagues (eg. Wolfe and Sidossis,
Am J Phys, 1996. 270: E733-E738)have proposed the reversal of this by
suggesting glucose uptake is "the substrate" which in fact determines
fuel selection. I believe I'm safe in saying that someone with an
appreciation for MCA would avoid saying that the there is one factor
which would determine fuel selection.
My question, in a very general sense, is can some of the readers of
this indicate to me if one could apply MCA to this fuel selection
problem and perhaps how you might do it.
I'm not so much interested in techniques but more from a
conceptual context. Since these differing hypotheses seem to focus on a single key
substrate it is not unlike those that look at a single rate
limiting enzyme in my mind.
Hopefully it's clear what I'm trying to say. If not, let me know and
may be able to clarify this.
Thanks,
Tom Wright
Dept of Animal and Poultry Science
University of Guelph
Guelph, ON
Canada
twright at aps.uoguelph.ca
--
