Tom C Wright wrote:
> [...] Randle et al hypothesis (and later ones
> which, in a nutshell, implicated intracellular fatty acids as reducing glucose
> oxidation. Recently, Wolfe and his colleagues (eg. Wolfe and Sidossis,
> Am J Phys, 1996. 270: E733-E738)have proposed the reversal of this by
> suggesting glucose uptake is "the substrate" which in fact determines
> fuel selection. I believe I'm safe in saying that someone with an
> appreciation for MCA would avoid saying that the there is one factor
> which would determine fuel selection.
>> My question, in a very general sense, is can some of the readers of
> this indicate to me if one could apply MCA to this fuel selection
> problem and perhaps how you might do it. [...]
Since none of the MCA experts seems to be reading / responding (this
newsgroup does go silent for months at end), I am going to ask: have you
tried some literature searches?
I just peeked into Medline (http://www.ncbi.nlm.nih.gov/entrez/) and
typed "glucose AND fuel selection". This gave about 50 papers, for
example:
Schwarz JM, Neese RA, Turner S, Dare D, Hellerstein MK
J Clin Invest 1995 Dec;96(6):2735-43
Short-term alterations in carbohydrate energy intake in humans. Striking
effects on hepatic glucose production, de novo lipogenesis, lipolysis,
and whole-body fuel selection.
No mention of MCA, though. It does not help that in Medline, "MCA" is
an established abbreviation for "middle cerebral artery".
-- Petr
_____________________________________________________________________
P e t r K u z m i c, Ph.D. mailto:pkuzmic at biokin.com
BioKin Ltd. * Software and Consulting http://www.biokin.com
