IUBio

metabolic simulators

Pedro Mendes mendes at vt.edu
Mon Apr 9 15:59:01 EST 2001


Ming Chen wrote:

> Both Gepasi and JARNAC are based on MCA,? why those tools simulated with
> differential equations are not so outstanding? is it the main reason that
> not all reaction kinetic equations are available or no universal one
> exist?

Actually both Gepasi and Jarnac are based on differential equations. They 
calculate MCA coefficients but the simulations are based on ODEs.

You are right that we do not have a universal kinetic law in biochemistry, 
but that in itself is not a problem in my opinion. (there is an approach, 
BST mostly from Savageau's work, which approximates kinetics with power 
laws)
-- 
Pedro Mendes
Virginia Bioinformatics Institute, Virginia Tech
1750 Kraft Drive, suite 1100, Blacksburg, VA 24060, USA
Phone: +1 540 2317411 Fax: +1 540 2311777




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