IUBio

Metabolic Simulation and informatics

Athel Cornish-Bowden athel at ir2cbm.cnrs-mrs.fr
Fri Jan 5 07:23:33 EST 2001


I said:

>> The most complete metabolic model I
>> know of is the model of glycolysis in Trypanosoma brucei worked out by
>> Barbara Bakker. Even that only includes around 60% of the numerical values

to which Douglas Kell said:
>
>(iv) I think there are larger models than Barbara's trypanosome one,

I didn't say "larger" (I'm sure there are many models bigger than
Barbara's), I said "most complete"

>though I am not sure how much they are based on hard experimental
>kinetic evidence.

Exactly

> think Bernard Palsson has some bigger ones but
>teh paper is not to hand. (I remember a poster at Il Ciocco 1989 by a
>guy from I think New Mexico that had SIX HUNDRED parameters for an
>erythrocyte model....never heard of it again).
>
Don't remember this. But in any case I'd want to know where all those 600
numbers came from. Off the top of someone's head isn't enough!

a.



--
Athel Cornish-Bowden    athel at ibsm.cnrs-mrs.fr
http://ir2lcb.cnrs-mrs.fr/~athel/homepage.htm
Phone: + 33 491 16 41 38;      fax: + 33 491 16 45 78
CNRS-BIP, B.P. 71, 13402 Marseille Cedex 20, France



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