At 12:24 PM -0800 1/12/01, Petr Kuzmic wrote:
>"Michael C. Kohn" wrote:
>> > [...] we learned how to use the matrix of
> > stoichiometries of the fast equilibria to compute corrections to the
> > time derivatives of chemicals (e.g. ATP) that appear in equations for
> > both fast equilibria and enzymatic reactions.
>>That's interesting. I must have missed that in the literature, if this
>method was ever published. Was it? Could one look at the code
>somewhere, and see exactly how this was done?
I believe it was published at least 20 years ago, but I can't
remember the details. You might try:
Garfinkel, Marbach, & Shapiro, Ann Rev Biophys Bioeng, 6, 525-542 (1977).
Roman et al., Comput Biomed Res, 11, 3-15 (1978).
Please let the group know if you find the paper.
Michael C. Kohn
Laboratory of Computational Biology and Risk Analysis
National Institute of Environmental Health Sciences
P.O. Box 12233, Mail Drop A3-06
Research Triangle Park, NC 27709-2233
919-541-4929 (voice)
919-541-1470 (Fax)
E-mail: kohn at valiant.niehs.nih.gov
Web site: http://valiant.niehs.nih.gov
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