dbk at aber.ac.uk ("Douglas Kell") wrote in message news:<3B3B0687.22335.3D386F38 at localhost>...
> I should know better than to respond to this...., but....
>> Transition state theory (TST) is not the only game in town so far as
> explaining 'how' enzymes work. In fact its chief assumption (a static
> energy barrier) is OBVIOUSLY untrue for the highly fluctuating things
> that enzymes are.
...
In addition to the very useful references posted by Douglas, I will
get on one of MY favored soap boxes and mention the name of Hans
Frauenfelder. Here are some of his papers, mostly elaborating the
concept of "ruggen energy landscape" and using myoglobin as the sample
system:
Frauenfelder H, McMahon BH, Austin RH, et al.
The role of structure, energy landscape, dynamics, and allostery
in the enzymatic function of myoglobin
P NATL ACAD SCI USA 98 (5): 2370-2374 FEB 27 2001
McMahon B, Frauenfelder H, Austin R, et al.
The role of structure, energy landscape, dynamics, and allostery
in the enzymatic function of myoglobin
BIOPHYS J 80 (1): 1180 Part 2 JAN 2001
Frauenfelder H, McMahon BH
Energy landscape and fluctuations in proteins
ANN PHYS-BERLIN 9 (9-10): 655-667 2000
McMahon BH, Stojkovic BP, Hay J, et al.
Structure/dynamics/function relationship in myoglobin
BIOPHYS J 78 (1): 1671Pos Part 2 JAN 2000
McMahon BH, Stjkovic BP, Frauenfelder H, et al.
Density functional theory calculation of barrier to ligand binding
in myoglobin
BIOPHYS J 76 (1): A23-A23 Part 2 JAN 1999
Frauenfelder H, Wolynes PG, Austin RH
Biological physics
REV MOD PHYS 71 (2): S419-S430 Sp. Iss. SI MAR 1999
Frauenfelder H, Leeson DT
The energy landscape in non-biological and biological molecules
NAT STRUCT BIOL 5 (9): 757-759 SEP 1998
Stojkovic BP, McMahon BH, Frauenfelder H, et al.
Molecular dynamics calculations of CO binding to myoglobin with an
abinitio calculated heme - CO interaction
potential.
ABSTR PAP AM CHEM S 216: 030-BIOL Part 1 AUG 23 1998
McMahon BH, Stojkovic BP, Frauenfelder H, et al.
Ab-initio calculation of heme - CO interaction potential.
ABSTR PAP AM CHEM S 216: 031-BIOL Part 1 AUG 23 1998
McMahon BH, Muller JD, Stojkovic B, et al.
Structural interpretation of CO recombination to myoglobin -
(5-320 K)
BIOPHYS J 74 (2): A236-A236 Part 2 FEB 1998
Frauenfelder H, McMahon B
Dynamics and function of proteins: The search for general concepts
P NATL ACAD SCI USA 95 (9): 4795-4797 APR 28 1998
Frauenfelder H, Bishop AR, Garcia A, et al.
Landscape paradigms in physics and biology - Concepts, structures
and dynamics - The 16th annual international
conference of the Center for Nonlinear Studies - Los Alamos, NM,
USA, 13-17 May 1996 - Preface
PHYSICA D 107 (2-4): R5-R5 SEP 1 1997
Nienhaus GU, Muller JD, McMahon BH, et al.
Exploring the conformational energy landscape of proteins
PHYSICA D 107 (2-4): 297-311 SEP 1 1997
Garcia AE, Krumhansl JA, Frauenfelder H
Variations on a theme by Debye and Waller: From simple crystals to
proteins
PROTEINS 29 (2): 153-160 OCT 1997
Frauenfelder H
Proteins: A challenging many-body problem
PHILOS MAG B 74 (5): 579-585 NOV 1996
Johnson JB, Lamb DC, Frauenfelder H, et al.
Ligand binding to heme proteins .6. Interconversion of taxonomic
substates in carbonmonoxymyoglobin
BIOPHYS J 71 (3): 1563-1573 SEP 1996
FRAUENFELDER H
COMPLEXITY IN PROTEINS
NAT STRUCT BIOL 2 (10): 821-823 OCT 1995
FRAUENFELDER H
FROM SYMMETRY TO COMPLEXITY
CHINESE J PHYS 32 (6): 1045-1050 Part 2 DEC 1994
FRAUENFELDER H
PROTEINS - PARADIGMS OF COMPLEX-SYSTEMS
EXPERIENTIA 51 (3): 200-203 MAR 15 1995
CHU K, ERNST RM, FRAUENFELDER H, et al.
LIGHT-INDUCED AND THERMAL RELAXATION IN A PROTEIN
PHYS REV LETT 74 (13): 2607-2610 MAR 27 1995
FRAUENFELDER H
THE MOSSBAUER-EFFECT AND BIOLOGICAL PHYSICS
HYPERFINE INTERACT 90 (1-4): 21-25 1994
- Petr
-------------------------------------------------------
P e t r K u z m i c, Ph. D. * BioKin Ltd.
1652 S. Grand Ave. * Suite 337 * Pullman, WA 99163
509.334.4131 * 509.332.3493 fax * http://www.biokin.com
