I remember more than ten years ago listening in awe to Fred
Opperdoes from Brussels giving a lecture about a joint project with
Rik Wieringa, then in Heidelberg, on triosephosphateisomerase.
They could show till the last hydrogen bridge how the intermediate
forms were stabilized and the transition between the intermediates
were facilitated. My conclusion would be that how enzymes work
also very much depends on the enzyme studied and that you are
likely to find different groups of mechanisms for different enzymes.
Benno ter Kuile
Benno ter Kuile
Leiden Institute of Chemistry, Gorlaeus Laboratories.
Leiden University;Einsteinweg 55 / P.O. Box 9502 2300RA, Leiden, The Netherlands.
Phone: +31 71 5275272 TeleFax: +31 71 5274537
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