Well, the intriguing thing about non-equilibrium system is that you still have to know about equilibrium.
If you don't know where equilibrium is, how can you tell if a system is out of equilibrium.
Furthermore,
knowing where is equilibrium, one can quantify the extend of disequilibrium. Equilibrium constant
(log K) gives you only delta G°, and that is only half of the story to the overall delta G. And the Q term
can help quantify disequilibrium energetics.
Gavin