David your comments are very interesting and when first reading the FAQ
for this group it also makes a mention of this, however I have never read
*how* MCA can be used in drug design and it kinda escapes me. Perhaps this
is a simple thing to point out. Perhaps someone's done it? Is your thought
the system level impact of a drug? How exactly do you go about doing this?
Len...
On 16 Jan 2002, David Fell wrote:
> Actually, I would say that the failure of the research effort is startling,
> because it goes beyond the two issues that Athel has commented on
> previously - the limitations of structure-based design and the failure to
> think of the system-level impact of a drug. There is no compelling
> evidence that other recent tools - combinatorial chemistry and high
> throughput screening - are yet leading to higher productivity. What is
> very impressive, on the other hand, is the rise in research costs per drug
> developed.
>> David Fell
