strange patterns of inheritance

Curtis Jamison jamison at news.cso.uiuc.edu
Wed Mar 22 13:14:11 EST 1995


In article <199503220222.AA04236 at ram.chiswick.anprod.csiro.au>, phunt at chiswick.anprod.CSIRO.AU (Peter Hunt) writes:
>Dear Worm Breeders,
>
>Please consider this hypothetical situation:
>
>Homozygotes for a mutation at X-linked locus (call it any) have a
>particular phenotype which is 100% penetrant in all selfed progeny.  BUT if
>you take hemizygous males and cross them with homozygous hermaphrodites
>then the phenotype of the resultant progeny is not 100% penetrant.
>So 100% of any/any animals which are self progeny have the mutant phenotype
>BUT <100% (say 80%) any/any animals which are the progeny of a cross
>between any/o males and any/any hermaphrodites have the mutant phenotype.
>
>What do you check to make sure that this result is real? (apart from
>checking that your parental strains are what you think they are).
>
>If it is real, then what are the possible explanations?
>
>Has anyone actually seen this (or something similar occur)?
>
>Any comments would be appreciated.
>
>Thanks.
>

Were the males heat-shocked from the original strain or were they
from a N2 male cross? If the latter, I would look for a background
autosomal gene which enhances the X-linked mutation.

Curt 
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Curt Jamison					     jamison at csl.ncsa.uiuc.edu
Assistant Director
Community Systems Laboratory
National Center for Supercomputing Applications
University of Illinois, Urbana-Champaign
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