Position on Nematode Globins in Edinburgh

Mark Blaxter m.blaxter at ic.ac.uk
Tue Mar 28 08:44:39 EST 1995


POST-DOCTORAL SCIENTIST
MOLECULAR GENETICS OF NEMATODE GLOBINS

Institute of Cell, Animal and Population Biology, University of Edinburgh

Nematodes express a number of globin isoforms which have remarkable
properties  (see Blaxter, Parasitology Today 9:353-360 [1993]). =
 This
project will use recombinant protein expression, transgenic and knockout
C.=A0elegans and crystallography to investigate the structure, function=
 and
evolution of these proteins.

The free-living nematode Caenorhabditis elegans has been chosen as=
 a
powerful model system for genetic and molecular analyses of neurobiology
and development.  It is now arguably the best known metazoan organism.=
=20
While often described as a model for eg the human genome project,=
 it is
also an excellent model nematode.  Serendipitously, C. elegans has=
 been
shown to have a globin gene, but nothing is yet known of its function=
 or
significance to the life of this soil nematode.  This project will=
 use C.
elegans as a testbed for the analysis of parasite globins in much=
 the same
way as it has been used to examine cellular interactions in development=
 or
nervous system function.  In particular, as it is possible to introduce
foreign genes into the C. elegans germline to create transgenic worms,=
 we
propose to construct C. elegans strains in which the parasite globins
replace the endogenous ones.  The function of the parasite genes=
 can then
be assayed in vivo but in the absence of the parasite.

The successful applicant will be joining a research group in nematode
genetics and molecular biology being set up by Dr. M.L. Blaxter who=
 is
taking up the position of Lecturer in Nematode Genetics at the Institute=
 of
Cell, Animal and Population Biology in Edinburgh from August 1995.

I am seeking an experienced and independent postdoctoral worker (starting
salary AR1A, point 9 [=A317,813 pa]) to join my research group in=
 nematode
genetics and molecular biology  The post is available for three years=
 from
1 August 1995..  Experience in molecular biology and protein biochemistry
will be essential, and familiarity with C.elegans an advantage.

Interested applicants should write, enclosing a cv and names of 2=
 referees, to

Dr. M.L. Blaxter, Department of Biology, Imperial College, London=
 SW7 2BB.

Informal enquiries will also be welcome:
e-mail to m.blaxter at ic.ac.uk
telephone +44 (0)171 594 5414

Closing date May 1st 1995.





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