imipramine and egg laying

Morris Maduro Morris_maduro at
Fri Jun 14 12:45:34 EST 1996

Dear Worm Folks,

I am having trouble using imipramine to stimulate egg laying even in N2
controls (I'm trying to test unc-119 mutants).  I have made a 0.75 mg/mL
solution in M9 of imipramine hydrochloride (Sigma I-7379) and even after
one hour in the solution there is no evidence of egg laying although the
animals survive the treatment quite readily.  Treatment with serotonin (10
mg/mL) works fine, so what could be going on here?


morris_maduro at

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