Has anyone tried to screen for EMS-induced mutations in C.elegans using DHPLC as used by McCallum et al (2000) Nature Biotech, 18, 455-457 on Arabidopsis? We have access to a WAVE DHPLC system and would like to try it. Colin Dolphin Dept of Pharmacy Kings College London London SE1 8WA colin.dolphin at kcl.ac.uk