subcellular localization of DNAses

[Robert Kuhelj, IJS]

Hi there,

has anyone got a clue about subcellular localization of mammalian DNAses, i.e.
which organelles contain these enzymes. Are any DNAses to be found in nucleus
as well?  What about the cytosol?

If one freezes a tissue sample and afterwards lets it thaw overnight, the
genomic DNA will be degraded. Are only lysosomal DNAses (lysosomes break
during freezing & thawing) responsible?

Thanks, Robert