subcellular localization of DNAses

Robert Kuhelj, IJS Robert.Kuhelj at
Thu Dec 2 08:31:16 EST 1993

Hi there,

has anyone got a clue about subcellular localization of mammalian DNAses, i.e.
which organelles contain these enzymes. Are any DNAses to be found in nucleus
as well?  What about the cytosol?

If one freezes a tissue sample and afterwards lets it thaw overnight, the
genomic DNA will be degraded. Are only lysosomal DNAses (lysosomes break
during freezing & thawing) responsible?

Thanks, Robert

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