Neutrophil activation with GTP[S]

Steven Debol Nelson sdebol at tsp.med.umn.edu
Sat Jul 17 00:21:04 EST 1993


Hello everyone:

My research deals with neutrophil signal transduction.  I have
been trying to use (unsuccessfully so far) an electropermeabilization
technique to create "leaky" neutrophils in order to activate
them with GTPgammaS.

My two questions:  Is anyone out there interested in neutrophil
signal transduction, and if so, familiar with this technique
and/or GTP[S]-stimulated neutrophil function.  I will be happy to
describe the technique in more detail--I am just "fishing" for
interested people right now!

Thanks in advance for any help!

Steve Debol
Dept. of Microbiology
University of Minnesota
sdebol at lenti.med.umn.edu



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