Agonist vs antagonist

George W Chacko gchacko at magnus.acs.ohio-state.edu
Fri Jul 23 14:21:55 EST 1993


In article <22p9d9$457 at reeve.research.aa.wl.com> dudleyd at aa.wl.com (Dave Dudley) writes:
>Does anyone know of examples where a ligand can act as an agonist at one
>receptor, and an antagonist at a subtype of that receptor?  Such as, a
>compound that is an agonist at m1 muscarinic receptors and an antagonist
>at m2 receptors?

Hmm! Monoclonal antibody 197 directed against human FcRI. It blocks
the binding of ligand (IgG) to the receptor but binds the receptor
with its Fc end. Well Fab end too. ;-)

George



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