targeting of MAP2b mRNA

Derek Milner dm690785 at mbcr.bcm.tmc.edu
Fri Apr 1 16:17:47 EST 1994


Keywords: MAP2b, mRNA, mRNA targeting, 3' UTR

I am interested in the process of targeting mRNAs to distinct subcellular
locations in neurons. One such transcript differentially localized in neurons is
the mRNA encoding the high molecular weight form of the microtubule associated
protein, MAP2b. Does anyone have any recent information on this subject? Studies
in other systems have shown that sequence elements in the 3' UTR of localized
mRNAs are necessary for correct localization. Has a sequence element been
identified for MAP2b mRNA that is necessary for correct targeting? Also, the
complete coding sequence for MAP2b has been cloned, but only a small segment of
untranslated mRNA sequence is known. Has any further MAP2b untranslated sequence
been isolated?  Any response will be appreciated. Thanks.

Derek

( dm690785 at mbcr.bcm.tmc.edu )
 




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