gordonr at cc.UManitoba.CA
Sat Dec 3 01:20:03 EST 1994
If apoptosis is a step of differentiation, then it may be initiated and
constrained by the trajactory of a differentiation wave. See:
Bjorklund, N.K. & R. Gordon (1993). Nuclear state splitting: a working
model for the mechanochemical coupling of differentiation waves to master
genes. Russian J. Dev. Biol. 24 (2), 79-95.
for a model that might be expandable to what you are seeking, and:
Bjorklund, N. K. & R. Gordon (1994). Surface contraction and expansion
waves correlated with differentiation in axolotl embryos. I. Prolegomenon
and differentiation during the plunge through the blastopore, as shown by
the fate map. Computers & Chemistry 18(3), 333-345.
for the latest on differentiation waves. Best regards, -Dick Gordon[Dec3,94]
On 2 Dec 1994 bordeaux at cwu.edu wrote:
> A lack of cellular growth signals can lead to programmed cell death,
apoptosis but during embryonic development some apoptosis is desireable
(for example, to
> get rid of the webbing between fingers and toes). However, too much cell
> death will occur if apoptosis is not controlled. Can anyone give me a model
> that will detail the events between the secretion of a hydrophobic steriod
> signal which is then presented to an embryonic human cell and ending with
> reduced levels of apoptosis in those cells?
> Any help at all would be appreciated more than you will ever know!
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