Fatty acid derivatization of signal transducers

Cornelius Krasel krasel at alf.biochem.mpg.de
Tue Jul 26 14:45:40 EST 1994


David Adelson (davead at prospect.anprod.csiro.au) wrote:

: Can anyone steer me towards a recent review or research paper which deals
: with the function of the myristyl or stearyl groups found on some signal
: transducers, eg pp60src.  Alternatively, if you have an opinion on this I
: would like to hear it.

IMHO, mostly neede for membrane anchoring and mediating protein-protein
interactions (unmodified beta- and gamma-G protein subunits are unable
to successfully interact). The catalytic subunit of PKA is also modified
by some fatty acid (can't recall which one) but this one is apparently
buried in the structure of the protein and may serve some structural role (?).

Some articles to read:

Reviews:

Christopher J. Marshall (1993): Protein prenylation: a mediator of protein-
protein interactions. Science 259, 1865--1866

Patrick J. Casey (1994): Lipid modifications of G proteins. Curr. Op.
Cell Biol. 6, 219--225

Research papers (arbitrarily chosen :-):

David Stokoe, Susan G. Macdonald, Karen Cadwallader, Marc Symons, John F.
Hancock (1994): Activation of Raf as a Result of Recruitment to the Plasma
Membrane. Science 264, 1463--1467

Sally J. Leevers, Hugh F. Paterson, Christopher J. Marshall (1994): Requirement
for Ras in Raf activation is overcome by targeting Raf to the plasma
membrane. Nature 369, 411--414

--Cornelius.

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/* Cornelius Krasel, Abt. Lohse, Genzentrum, D-82152 Martinsried, Germany */
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